Clinical importance of persistence of anticardiolipin antibodies in systemic lupus erythematosus

Y. Ishii, K. Nagasawa, T. Mayumi, Y. Niho

研究成果: Contribution to journalArticle査読

60 被引用数 (Scopus)

抄録

The clinical importance of IgG anticardiolipin antibodies was investigated in systemic lupus erythematosus (SLE). IgG anticardiolipin antibodies were found in 69 of 155 (44-5%) patients with SLE. Serial measurements of IgG anticardiolipin antibodies allowed the patients to be classified into two groups: group A, persistently positive for IgG anticardiolipin antibodies; group B, positive only in active phases. The IgG anticardiolipin antibody litre in group A was significantly higher than in group B. The incidence of thromboses, spontaneous abortions, and lupus anticoagulant in group A was significantly higher than in group B (p < 0-05). By contrast, the incidence of renal diseases and anti-dsDNA antibodies in group B was significantly higher than in group A (p < 0-05). This study showed that group A formed a separate subgroup of patients with SLE who had a high risk of thromboses and spontaneous abortions despite having milder disease activity.

本文言語英語
ページ(範囲)387-390
ページ数4
ジャーナルAnnals of the Rheumatic Diseases
49
6
DOI
出版ステータス出版済み - 1990
外部発表はい

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Ophthalmology
  • Sensory Systems
  • Immunology
  • Rheumatology

フィンガープリント 「Clinical importance of persistence of anticardiolipin antibodies in systemic lupus erythematosus」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル