Clinical importance of persistence of anticardiolipin antibodies in systemic lupus erythematosus

Y. Ishii, K. Nagasawa, T. Mayumi, Y. Niho

研究成果: ジャーナルへの寄稿学術誌査読

61 被引用数 (Scopus)

抄録

The clinical importance of IgG anticardiolipin antibodies was investigated in systemic lupus erythematosus (SLE). IgG anticardiolipin antibodies were found in 69 of 155 (44-5%) patients with SLE. Serial measurements of IgG anticardiolipin antibodies allowed the patients to be classified into two groups: group A, persistently positive for IgG anticardiolipin antibodies; group B, positive only in active phases. The IgG anticardiolipin antibody litre in group A was significantly higher than in group B. The incidence of thromboses, spontaneous abortions, and lupus anticoagulant in group A was significantly higher than in group B (p < 0-05). By contrast, the incidence of renal diseases and anti-dsDNA antibodies in group B was significantly higher than in group A (p < 0-05). This study showed that group A formed a separate subgroup of patients with SLE who had a high risk of thromboses and spontaneous abortions despite having milder disease activity.

本文言語英語
ページ(範囲)387-390
ページ数4
ジャーナルAnnals of the Rheumatic Diseases
49
6
DOI
出版ステータス出版済み - 1990
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 細胞および分子神経科学
  • 眼科学
  • 感覚系
  • 免疫学
  • リウマチ学

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