Clinical outcome and prognostic factors of malignant spinal dumbbell tumors

研究成果: ジャーナルへの寄稿記事

抄録

Introduction: To investigate the clinical outcome and prognostic factors of malignant spinal dumbbell tumors (m-SDTs). Methods: We retrospectively reviewed the clinical outcome of 22 consecutive cases of m-SDTs and analyzed the prognostic factors associated with worse outcome. Results: Nineteen of the 22 cases were managed with surgery (86%), and gross total resection (GTR) was achieved in four cases (21%). The duration of overall survival (OS) ranged from 3 to 140 months, with a median survival time of 15.3 months. The 5 year OS rate was 55.6%. In multivariate analysis, histological subtype (high-grade malignant peripheral nerve sheath tumor) (hazard ratio [HR] 14.9, p = 0.0191), GTR (HR 0.07, p = 0.0343), and presence of local recurrences (HR 11.2, p = 0.0479) were significant and independent predictors of OS. Conclusions: On the basis of clinical data, we propose that GTR and prevention of local recurrence may improve the clinical outcome of m-SDTs.

元の言語英語
ページ(範囲)317-323
ページ数7
ジャーナルSpine Surgery and Related Research
2
発行部数4
DOI
出版物ステータス出版済み - 1 1 2018

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Recurrence
Neoplasms
Neurilemmoma
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology
  • Orthopedics and Sports Medicine

これを引用

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title = "Clinical outcome and prognostic factors of malignant spinal dumbbell tumors",
abstract = "Introduction: To investigate the clinical outcome and prognostic factors of malignant spinal dumbbell tumors (m-SDTs). Methods: We retrospectively reviewed the clinical outcome of 22 consecutive cases of m-SDTs and analyzed the prognostic factors associated with worse outcome. Results: Nineteen of the 22 cases were managed with surgery (86{\%}), and gross total resection (GTR) was achieved in four cases (21{\%}). The duration of overall survival (OS) ranged from 3 to 140 months, with a median survival time of 15.3 months. The 5 year OS rate was 55.6{\%}. In multivariate analysis, histological subtype (high-grade malignant peripheral nerve sheath tumor) (hazard ratio [HR] 14.9, p = 0.0191), GTR (HR 0.07, p = 0.0343), and presence of local recurrences (HR 11.2, p = 0.0479) were significant and independent predictors of OS. Conclusions: On the basis of clinical data, we propose that GTR and prevention of local recurrence may improve the clinical outcome of m-SDTs.",
author = "Yoshihiro Matsumoto and Kenichi Kawaguchi and Fukushi, {Jun ichi} and Makoto Endo and Nokitaka Setsu and Keiichiro Iida and Satoshi Baba and Hirokazu Saiwai and Akinobu Matsushita and Mitsumasa Hayashida and Seiji Okada and Yasuharu Nakashima",
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TY - JOUR

T1 - Clinical outcome and prognostic factors of malignant spinal dumbbell tumors

AU - Matsumoto, Yoshihiro

AU - Kawaguchi, Kenichi

AU - Fukushi, Jun ichi

AU - Endo, Makoto

AU - Setsu, Nokitaka

AU - Iida, Keiichiro

AU - Baba, Satoshi

AU - Saiwai, Hirokazu

AU - Matsushita, Akinobu

AU - Hayashida, Mitsumasa

AU - Okada, Seiji

AU - Nakashima, Yasuharu

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Introduction: To investigate the clinical outcome and prognostic factors of malignant spinal dumbbell tumors (m-SDTs). Methods: We retrospectively reviewed the clinical outcome of 22 consecutive cases of m-SDTs and analyzed the prognostic factors associated with worse outcome. Results: Nineteen of the 22 cases were managed with surgery (86%), and gross total resection (GTR) was achieved in four cases (21%). The duration of overall survival (OS) ranged from 3 to 140 months, with a median survival time of 15.3 months. The 5 year OS rate was 55.6%. In multivariate analysis, histological subtype (high-grade malignant peripheral nerve sheath tumor) (hazard ratio [HR] 14.9, p = 0.0191), GTR (HR 0.07, p = 0.0343), and presence of local recurrences (HR 11.2, p = 0.0479) were significant and independent predictors of OS. Conclusions: On the basis of clinical data, we propose that GTR and prevention of local recurrence may improve the clinical outcome of m-SDTs.

AB - Introduction: To investigate the clinical outcome and prognostic factors of malignant spinal dumbbell tumors (m-SDTs). Methods: We retrospectively reviewed the clinical outcome of 22 consecutive cases of m-SDTs and analyzed the prognostic factors associated with worse outcome. Results: Nineteen of the 22 cases were managed with surgery (86%), and gross total resection (GTR) was achieved in four cases (21%). The duration of overall survival (OS) ranged from 3 to 140 months, with a median survival time of 15.3 months. The 5 year OS rate was 55.6%. In multivariate analysis, histological subtype (high-grade malignant peripheral nerve sheath tumor) (hazard ratio [HR] 14.9, p = 0.0191), GTR (HR 0.07, p = 0.0343), and presence of local recurrences (HR 11.2, p = 0.0479) were significant and independent predictors of OS. Conclusions: On the basis of clinical data, we propose that GTR and prevention of local recurrence may improve the clinical outcome of m-SDTs.

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U2 - 10.22603/ssrr.2018-0004

DO - 10.22603/ssrr.2018-0004

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