Clinical outcome and prognostic factors of malignant spinal dumbbell tumors

Yoshihiro Matsumoto, Kenichi Kawaguchi, Jun ichi Fukushi, Makoto Endo, Nokitaka Setsu, Keiichiro Iida, Satoshi Baba, Hirokazu Saiwai, Akinobu Matsushita, Mitsumasa Hayashida, Seiji Okada, Yasuharu Nakashima

研究成果: Contribution to journalArticle査読

抄録

Introduction: To investigate the clinical outcome and prognostic factors of malignant spinal dumbbell tumors (m-SDTs). Methods: We retrospectively reviewed the clinical outcome of 22 consecutive cases of m-SDTs and analyzed the prognostic factors associated with worse outcome. Results: Nineteen of the 22 cases were managed with surgery (86%), and gross total resection (GTR) was achieved in four cases (21%). The duration of overall survival (OS) ranged from 3 to 140 months, with a median survival time of 15.3 months. The 5 year OS rate was 55.6%. In multivariate analysis, histological subtype (high-grade malignant peripheral nerve sheath tumor) (hazard ratio [HR] 14.9, p = 0.0191), GTR (HR 0.07, p = 0.0343), and presence of local recurrences (HR 11.2, p = 0.0479) were significant and independent predictors of OS. Conclusions: On the basis of clinical data, we propose that GTR and prevention of local recurrence may improve the clinical outcome of m-SDTs.

本文言語英語
ページ(範囲)317-323
ページ数7
ジャーナルSpine Surgery and Related Research
2
4
DOI
出版ステータス出版済み - 2018

All Science Journal Classification (ASJC) codes

  • 外科
  • 整形外科およびスポーツ医学
  • 臨床神経学

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