TY - JOUR
T1 - Clinical outcome and prognostic factors of malignant spinal dumbbell tumors
AU - Matsumoto, Yoshihiro
AU - Kawaguchi, Kenichi
AU - Fukushi, Jun ichi
AU - Endo, Makoto
AU - Setsu, Nokitaka
AU - Iida, Keiichiro
AU - Baba, Satoshi
AU - Saiwai, Hirokazu
AU - Matsushita, Akinobu
AU - Hayashida, Mitsumasa
AU - Okada, Seiji
AU - Nakashima, Yasuharu
N1 - Funding Information:
Sources of Funding: This work was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (#15K10499).
Publisher Copyright:
Copyright © 2018 The Japanese Society for Spine Surgery and Related Research.
PY - 2018
Y1 - 2018
N2 - Introduction: To investigate the clinical outcome and prognostic factors of malignant spinal dumbbell tumors (m-SDTs). Methods: We retrospectively reviewed the clinical outcome of 22 consecutive cases of m-SDTs and analyzed the prognostic factors associated with worse outcome. Results: Nineteen of the 22 cases were managed with surgery (86%), and gross total resection (GTR) was achieved in four cases (21%). The duration of overall survival (OS) ranged from 3 to 140 months, with a median survival time of 15.3 months. The 5 year OS rate was 55.6%. In multivariate analysis, histological subtype (high-grade malignant peripheral nerve sheath tumor) (hazard ratio [HR] 14.9, p = 0.0191), GTR (HR 0.07, p = 0.0343), and presence of local recurrences (HR 11.2, p = 0.0479) were significant and independent predictors of OS. Conclusions: On the basis of clinical data, we propose that GTR and prevention of local recurrence may improve the clinical outcome of m-SDTs.
AB - Introduction: To investigate the clinical outcome and prognostic factors of malignant spinal dumbbell tumors (m-SDTs). Methods: We retrospectively reviewed the clinical outcome of 22 consecutive cases of m-SDTs and analyzed the prognostic factors associated with worse outcome. Results: Nineteen of the 22 cases were managed with surgery (86%), and gross total resection (GTR) was achieved in four cases (21%). The duration of overall survival (OS) ranged from 3 to 140 months, with a median survival time of 15.3 months. The 5 year OS rate was 55.6%. In multivariate analysis, histological subtype (high-grade malignant peripheral nerve sheath tumor) (hazard ratio [HR] 14.9, p = 0.0191), GTR (HR 0.07, p = 0.0343), and presence of local recurrences (HR 11.2, p = 0.0479) were significant and independent predictors of OS. Conclusions: On the basis of clinical data, we propose that GTR and prevention of local recurrence may improve the clinical outcome of m-SDTs.
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U2 - 10.22603/ssrr.2018-0004
DO - 10.22603/ssrr.2018-0004
M3 - Article
AN - SCOPUS:85071278487
VL - 2
SP - 317
EP - 323
JO - Spine Surgery and Related Research
JF - Spine Surgery and Related Research
SN - 2432-261X
IS - 4
ER -