Clinical outcomes of a novel therapeutic vaccine with Tax peptide-pulsed dendritic cells for adult T cell leukaemia/lymphoma in a pilot study

Youko Suehiro, Atsuhiko Hasegawa, Tadafumi Iino, Amane Sasada, Nobukazu Watanabe, Masao Matsuoka, Ayako Takamori, Ryuji Tanosaki, Atae Utsunomiya, Ilseung Choi, Tetsuya Fukuda, Osamu Miura, Shigeo Takaishi, Takanori Teshima, Koichi Akashi, Mari Kannagi, Naokuni Uike, Jun Okamura

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Adult T cell leukaemia/lymphoma (ATL) is a human T cell leukaemia virus type-I (HTLV-I)-infected T cell malignancy with poor prognosis. We herein developed a novel therapeutic vaccine designed to augment an HTLV-I Tax-specific cytotoxic T lymphocyte (CTL) response that has been implicated in anti-ATL effects, and conducted a pilot study to investigate its safety and efficacy. Three previously treated ATL patients, classified as intermediate- to high-risk, were subcutaneously administered with the vaccine, consisting of autologous dendritic cells (DCs) pulsed with Tax peptides corresponding to the CTL epitopes. In all patients, the performance status improved after vaccination without severe adverse events, and Tax-specific CTL responses were observed with peaks at 16-20 weeks. Two patients achieved partial remission in the first 8 weeks, one of whom later achieved complete remission, maintaining their remission status without any additional chemotherapy 24 and 19 months after vaccination, respectively. The third patient, whose tumour cells lacked the ability to express Tax at biopsy, obtained stable disease in the first 8 weeks and later developed slowly progressive disease although additional therapy was not required for 14 months. The clinical outcomes of this pilot study indicate that the Tax peptide-pulsed DC vaccine is a safe and promising immunotherapy for ATL.

元の言語英語
ページ(範囲)356-367
ページ数12
ジャーナルBritish Journal of Haematology
169
発行部数3
DOI
出版物ステータス出版済み - 5 1 2015

All Science Journal Classification (ASJC) codes

  • Hematology

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    Suehiro, Y., Hasegawa, A., Iino, T., Sasada, A., Watanabe, N., Matsuoka, M., Takamori, A., Tanosaki, R., Utsunomiya, A., Choi, I., Fukuda, T., Miura, O., Takaishi, S., Teshima, T., Akashi, K., Kannagi, M., Uike, N., & Okamura, J. (2015). Clinical outcomes of a novel therapeutic vaccine with Tax peptide-pulsed dendritic cells for adult T cell leukaemia/lymphoma in a pilot study. British Journal of Haematology, 169(3), 356-367. https://doi.org/10.1111/bjh.13302