[Clinical outcomes of allogeneic hematopoietic stem cell transplantation for adult primary myelofibrosis

retrospective analysis by Fukuoka BMT group].

Tomohiko Kamimura, Yong Jeong, Yoshikiyo Ito, Hideho Henzan, Toshihiro Miyamoto, Yusyu Ohno, Tetsuya Eto, Katsuto Takenaka, Koichi Akashi

研究成果: ジャーナルへの寄稿評論記事

抄録

We retrospectively analyzed outcomes of eight evaluable patients with primary myelofibrosis (PMF) who received allogeneic hematopoietic stem cell transplantation (allo-HSCT), using different graft sources; four patients received peripheral blood stem cells, three bone marrow, and one umbilical cord blood. The median age was 48 years (range, 43~64 years). Seven patients had an intermediate or high Dupriez score. Three patients underwent myeloablative conditioning, whereas five underwent reduced-intensity conditioning regimens. Engraftment was obtained in all of these recipients. The median days to reach a neutrophil count above 0.5×10(9)/l and platelet count above 20×10(9)/l were 20 and 35 days, respectively. No treatment-related deaths were observed within 100 days after allo-HSCT. Two patients died of sepsis or late-onset non-infectious pulmonary complications. Four patients developed grade I to II acute GVHD, and six patients developed chronic GVHD. The estimated 3-year overall survival was 75% with a median follow up time of 43 months (range, 6~127). Four of 5 patients who were transfusion-dependent became free from transfusion after allo-HSCT. In six of seven patients, a regression of fibrosis was confirmed by bone marrow biopsy. Despite the small number of cases, our results suggested that allo-HSCT is an encouraging curative strategy for treating PMF.

元の言語英語
ページ(範囲)323-328
ページ数6
ジャーナル[Rinshō ketsueki] The Japanese journal of clinical hematology
53
発行部数3
出版物ステータス出版済み - 1 1 2012

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Primary Myelofibrosis
Hematopoietic Stem Cell Transplantation
Bone Marrow
Platelet Count
Fetal Blood
Sepsis
Neutrophils
Fibrosis
Transplants
Biopsy
Lung
Survival

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

[Clinical outcomes of allogeneic hematopoietic stem cell transplantation for adult primary myelofibrosis : retrospective analysis by Fukuoka BMT group]. / Kamimura, Tomohiko; Jeong, Yong; Ito, Yoshikiyo; Henzan, Hideho; Miyamoto, Toshihiro; Ohno, Yusyu; Eto, Tetsuya; Takenaka, Katsuto; Akashi, Koichi.

:: [Rinshō ketsueki] The Japanese journal of clinical hematology, 巻 53, 番号 3, 01.01.2012, p. 323-328.

研究成果: ジャーナルへの寄稿評論記事

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title = "[Clinical outcomes of allogeneic hematopoietic stem cell transplantation for adult primary myelofibrosis: retrospective analysis by Fukuoka BMT group].",
abstract = "We retrospectively analyzed outcomes of eight evaluable patients with primary myelofibrosis (PMF) who received allogeneic hematopoietic stem cell transplantation (allo-HSCT), using different graft sources; four patients received peripheral blood stem cells, three bone marrow, and one umbilical cord blood. The median age was 48 years (range, 43~64 years). Seven patients had an intermediate or high Dupriez score. Three patients underwent myeloablative conditioning, whereas five underwent reduced-intensity conditioning regimens. Engraftment was obtained in all of these recipients. The median days to reach a neutrophil count above 0.5×10(9)/l and platelet count above 20×10(9)/l were 20 and 35 days, respectively. No treatment-related deaths were observed within 100 days after allo-HSCT. Two patients died of sepsis or late-onset non-infectious pulmonary complications. Four patients developed grade I to II acute GVHD, and six patients developed chronic GVHD. The estimated 3-year overall survival was 75{\%} with a median follow up time of 43 months (range, 6~127). Four of 5 patients who were transfusion-dependent became free from transfusion after allo-HSCT. In six of seven patients, a regression of fibrosis was confirmed by bone marrow biopsy. Despite the small number of cases, our results suggested that allo-HSCT is an encouraging curative strategy for treating PMF.",
author = "Tomohiko Kamimura and Yong Jeong and Yoshikiyo Ito and Hideho Henzan and Toshihiro Miyamoto and Yusyu Ohno and Tetsuya Eto and Katsuto Takenaka and Koichi Akashi",
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AU - Kamimura, Tomohiko

AU - Jeong, Yong

AU - Ito, Yoshikiyo

AU - Henzan, Hideho

AU - Miyamoto, Toshihiro

AU - Ohno, Yusyu

AU - Eto, Tetsuya

AU - Takenaka, Katsuto

AU - Akashi, Koichi

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N2 - We retrospectively analyzed outcomes of eight evaluable patients with primary myelofibrosis (PMF) who received allogeneic hematopoietic stem cell transplantation (allo-HSCT), using different graft sources; four patients received peripheral blood stem cells, three bone marrow, and one umbilical cord blood. The median age was 48 years (range, 43~64 years). Seven patients had an intermediate or high Dupriez score. Three patients underwent myeloablative conditioning, whereas five underwent reduced-intensity conditioning regimens. Engraftment was obtained in all of these recipients. The median days to reach a neutrophil count above 0.5×10(9)/l and platelet count above 20×10(9)/l were 20 and 35 days, respectively. No treatment-related deaths were observed within 100 days after allo-HSCT. Two patients died of sepsis or late-onset non-infectious pulmonary complications. Four patients developed grade I to II acute GVHD, and six patients developed chronic GVHD. The estimated 3-year overall survival was 75% with a median follow up time of 43 months (range, 6~127). Four of 5 patients who were transfusion-dependent became free from transfusion after allo-HSCT. In six of seven patients, a regression of fibrosis was confirmed by bone marrow biopsy. Despite the small number of cases, our results suggested that allo-HSCT is an encouraging curative strategy for treating PMF.

AB - We retrospectively analyzed outcomes of eight evaluable patients with primary myelofibrosis (PMF) who received allogeneic hematopoietic stem cell transplantation (allo-HSCT), using different graft sources; four patients received peripheral blood stem cells, three bone marrow, and one umbilical cord blood. The median age was 48 years (range, 43~64 years). Seven patients had an intermediate or high Dupriez score. Three patients underwent myeloablative conditioning, whereas five underwent reduced-intensity conditioning regimens. Engraftment was obtained in all of these recipients. The median days to reach a neutrophil count above 0.5×10(9)/l and platelet count above 20×10(9)/l were 20 and 35 days, respectively. No treatment-related deaths were observed within 100 days after allo-HSCT. Two patients died of sepsis or late-onset non-infectious pulmonary complications. Four patients developed grade I to II acute GVHD, and six patients developed chronic GVHD. The estimated 3-year overall survival was 75% with a median follow up time of 43 months (range, 6~127). Four of 5 patients who were transfusion-dependent became free from transfusion after allo-HSCT. In six of seven patients, a regression of fibrosis was confirmed by bone marrow biopsy. Despite the small number of cases, our results suggested that allo-HSCT is an encouraging curative strategy for treating PMF.

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