Clinical significance of ASB9 in human colorectal cancer

Masayoshi Tokuoka, Norikatsu Miyoshi, Toshiki Hitora, Koshi Mimori, Fumiaki Tanaka, Koichi Shibata, Hideshi Ishii, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

研究成果: ジャーナルへの寄稿学術誌査読

18 被引用数 (Scopus)

抄録

Ankyrin repeat and SOCS box-containing 9 (ASB9) is involved in the negative regulation of cytokine signaling. However, its biological function is largely undefined. The aim of this study was to assess the value and role of ASB9 as an indicator of prognosis in colorectal cancer (CRC). In order to demonstrate the importance of ASB9 expression for predicting the prognosis of CRC, we analyzed the ASB9 mRNA expression in 125 paired cases of CRC and non-cancerous regions and the protein expression by immunohistochemistry. To investigate the role of ASB9 in vitro, we performed proliferation and invasion assay with small interfering RNA against ASB9. ASB9 mRNA expression was higher in CRC tissue than corresponding normal tissue (P=0.0282). Patients expressing low levels of ASB9 had a poorer overall survival rate than those expressing high levels (P=0.0301), indicating that decreased ASB9 expression was an independent prognostic factor. The immunohistochemical study revealed that ASB9 was predominantly expressed in cancer cells. A multivariate analysis showed that ASB9 expression status was an independent prognostic factor of overall survival (relative risk, 4.09; 95% confidence interval, 1.47-11.88; P=0.007). In an invasion assay, ASB9 siRNA-transfected cells showed significantly high invasiveness. The results of the present study suggest that ASB9 is a useful prognostic marker for CRC.

本文言語英語
ページ(範囲)1105-1111
ページ数7
ジャーナルInternational journal of oncology
37
5
DOI
出版ステータス出版済み - 11月 2010

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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