Clinical significance of CXCR4 and CCR7 chemokine receptor expression in uterine cervical cancer

Kenzo Sonoda

研究成果: Contribution to journalArticle査読

抄録

Evaluation of: Kodama J, Hasengaowa, Kusumoto T et al. Association of CXCR4 and CCR7 chemokine receptor expression and lymph node metastasis in human cervical cancer. Ann. Oncol. 18, 70–76 (2007). Previous reports have suggested that chemokine receptors play a pivotal role in cancer invasion and metastasis. However, expression of chemokine receptors in uterine cervical cancer has seldom been evaluated. Using immunohistochemical methods, Kodama and colleagues investigated an association between CXCR4 and CCR7 expression and clinicopathological variables. They used logistic regression analysis to reveal that CXCR4 and CCR7 are independent factors influencing pelvic lymph node metastasis. Moreover, CXCR4 and CCR7 expression are independent prognostic factors for overall patient survival rates. These data demonstrate the clinical significance of CXCR4 and CCR7 expression for lymph node metastasis in uterine cervical cancer.

本文言語英語
ページ(範囲)129-132
ページ数4
ジャーナルExpert Review of Obstetrics and Gynecology
2
2
DOI
出版ステータス出版済み - 3 1 2007

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 生殖医学
  • 産婦人科学
  • 母性および助産

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