Clinical Significance of Expression of Nephroblastoma Overexpressed (NOV) in Patients with Colorectal Cancer

Masami Ueda, Tomohiro Iguchi, Hisateru Komatsu, Shinya Kidogami, Qingjiang Hu, Kuniaki Sato, Yushi Ogawa, Sho Nambara, Tomoko Saito, Shotaro Sakimura, Hidenari Hirata, Ryutaro Uchi, Yoshiaki Shinden, Hidetoshi Eguchi, Shuhei Ito, Takaaki Masuda, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori, Koshi Mimori

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

BACKGROUND: The nephroblastoma overexpressed (NOV) gene, which belongs to the cysteine-rich, angiogenic inducer 61/connective tissue growth factor/nephroblastoma overexpressed (CCN) family, is located in the 8q24 region and promotes migration and invasiveness in several types of malignancies. We explored the clinical significance of NOV expression in colorectal cancer (CRC).

MATERIALS AND METHODS: NOV expression in CRC specimens and CRC cell lines were evaluated. The association between the clinicopathlogical factors and NOV mRNA expression of tumor tissues was assessed in 126 patients with CRC. We assessed the relationships between NOV expression and overall survival in public databases. We performed overexpression experiments in vitro.

RESULTS: CRC specimens and CRC cell lines showed high NOV expression. High NOV mRNA expression was correlated with poorer overall survival and higher Union for International Cancer Control (UICC) T factor. In public databases, high NOV expression was associated with poorer prognoses. Overexpression of NOV promoted invasiveness of CRC cells.

CONCLUSION: NOV may be an indicator of poor prognosis and a therapeutic target in CRC.

元の言語英語
ページ(範囲)6591-6597
ページ数7
ジャーナルAnticancer research
35
発行部数12
出版物ステータス出版済み - 12 1 2015

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Wilms Tumor
Colorectal Neoplasms
Databases
Connective Tissue Growth Factor
Cell Line
Neoplasms
Messenger RNA
Survival
Cysteine

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Ueda, M., Iguchi, T., Komatsu, H., Kidogami, S., Hu, Q., Sato, K., ... Mimori, K. (2015). Clinical Significance of Expression of Nephroblastoma Overexpressed (NOV) in Patients with Colorectal Cancer. Anticancer research, 35(12), 6591-6597.

Clinical Significance of Expression of Nephroblastoma Overexpressed (NOV) in Patients with Colorectal Cancer. / Ueda, Masami; Iguchi, Tomohiro; Komatsu, Hisateru; Kidogami, Shinya; Hu, Qingjiang; Sato, Kuniaki; Ogawa, Yushi; Nambara, Sho; Saito, Tomoko; Sakimura, Shotaro; Hirata, Hidenari; Uchi, Ryutaro; Shinden, Yoshiaki; Eguchi, Hidetoshi; Ito, Shuhei; Masuda, Takaaki; Yamamoto, Hirofumi; Doki, Yuichiro; Mori, Masaki; Mimori, Koshi.

:: Anticancer research, 巻 35, 番号 12, 01.12.2015, p. 6591-6597.

研究成果: ジャーナルへの寄稿記事

Ueda, M, Iguchi, T, Komatsu, H, Kidogami, S, Hu, Q, Sato, K, Ogawa, Y, Nambara, S, Saito, T, Sakimura, S, Hirata, H, Uchi, R, Shinden, Y, Eguchi, H, Ito, S, Masuda, T, Yamamoto, H, Doki, Y, Mori, M & Mimori, K 2015, 'Clinical Significance of Expression of Nephroblastoma Overexpressed (NOV) in Patients with Colorectal Cancer', Anticancer research, 巻. 35, 番号 12, pp. 6591-6597.
Ueda M, Iguchi T, Komatsu H, Kidogami S, Hu Q, Sato K その他. Clinical Significance of Expression of Nephroblastoma Overexpressed (NOV) in Patients with Colorectal Cancer. Anticancer research. 2015 12 1;35(12):6591-6597.
Ueda, Masami ; Iguchi, Tomohiro ; Komatsu, Hisateru ; Kidogami, Shinya ; Hu, Qingjiang ; Sato, Kuniaki ; Ogawa, Yushi ; Nambara, Sho ; Saito, Tomoko ; Sakimura, Shotaro ; Hirata, Hidenari ; Uchi, Ryutaro ; Shinden, Yoshiaki ; Eguchi, Hidetoshi ; Ito, Shuhei ; Masuda, Takaaki ; Yamamoto, Hirofumi ; Doki, Yuichiro ; Mori, Masaki ; Mimori, Koshi. / Clinical Significance of Expression of Nephroblastoma Overexpressed (NOV) in Patients with Colorectal Cancer. :: Anticancer research. 2015 ; 巻 35, 番号 12. pp. 6591-6597.
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title = "Clinical Significance of Expression of Nephroblastoma Overexpressed (NOV) in Patients with Colorectal Cancer",
abstract = "BACKGROUND: The nephroblastoma overexpressed (NOV) gene, which belongs to the cysteine-rich, angiogenic inducer 61/connective tissue growth factor/nephroblastoma overexpressed (CCN) family, is located in the 8q24 region and promotes migration and invasiveness in several types of malignancies. We explored the clinical significance of NOV expression in colorectal cancer (CRC).MATERIALS AND METHODS: NOV expression in CRC specimens and CRC cell lines were evaluated. The association between the clinicopathlogical factors and NOV mRNA expression of tumor tissues was assessed in 126 patients with CRC. We assessed the relationships between NOV expression and overall survival in public databases. We performed overexpression experiments in vitro.RESULTS: CRC specimens and CRC cell lines showed high NOV expression. High NOV mRNA expression was correlated with poorer overall survival and higher Union for International Cancer Control (UICC) T factor. In public databases, high NOV expression was associated with poorer prognoses. Overexpression of NOV promoted invasiveness of CRC cells.CONCLUSION: NOV may be an indicator of poor prognosis and a therapeutic target in CRC.",
author = "Masami Ueda and Tomohiro Iguchi and Hisateru Komatsu and Shinya Kidogami and Qingjiang Hu and Kuniaki Sato and Yushi Ogawa and Sho Nambara and Tomoko Saito and Shotaro Sakimura and Hidenari Hirata and Ryutaro Uchi and Yoshiaki Shinden and Hidetoshi Eguchi and Shuhei Ito and Takaaki Masuda and Hirofumi Yamamoto and Yuichiro Doki and Masaki Mori and Koshi Mimori",
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T1 - Clinical Significance of Expression of Nephroblastoma Overexpressed (NOV) in Patients with Colorectal Cancer

AU - Ueda, Masami

AU - Iguchi, Tomohiro

AU - Komatsu, Hisateru

AU - Kidogami, Shinya

AU - Hu, Qingjiang

AU - Sato, Kuniaki

AU - Ogawa, Yushi

AU - Nambara, Sho

AU - Saito, Tomoko

AU - Sakimura, Shotaro

AU - Hirata, Hidenari

AU - Uchi, Ryutaro

AU - Shinden, Yoshiaki

AU - Eguchi, Hidetoshi

AU - Ito, Shuhei

AU - Masuda, Takaaki

AU - Yamamoto, Hirofumi

AU - Doki, Yuichiro

AU - Mori, Masaki

AU - Mimori, Koshi

PY - 2015/12/1

Y1 - 2015/12/1

N2 - BACKGROUND: The nephroblastoma overexpressed (NOV) gene, which belongs to the cysteine-rich, angiogenic inducer 61/connective tissue growth factor/nephroblastoma overexpressed (CCN) family, is located in the 8q24 region and promotes migration and invasiveness in several types of malignancies. We explored the clinical significance of NOV expression in colorectal cancer (CRC).MATERIALS AND METHODS: NOV expression in CRC specimens and CRC cell lines were evaluated. The association between the clinicopathlogical factors and NOV mRNA expression of tumor tissues was assessed in 126 patients with CRC. We assessed the relationships between NOV expression and overall survival in public databases. We performed overexpression experiments in vitro.RESULTS: CRC specimens and CRC cell lines showed high NOV expression. High NOV mRNA expression was correlated with poorer overall survival and higher Union for International Cancer Control (UICC) T factor. In public databases, high NOV expression was associated with poorer prognoses. Overexpression of NOV promoted invasiveness of CRC cells.CONCLUSION: NOV may be an indicator of poor prognosis and a therapeutic target in CRC.

AB - BACKGROUND: The nephroblastoma overexpressed (NOV) gene, which belongs to the cysteine-rich, angiogenic inducer 61/connective tissue growth factor/nephroblastoma overexpressed (CCN) family, is located in the 8q24 region and promotes migration and invasiveness in several types of malignancies. We explored the clinical significance of NOV expression in colorectal cancer (CRC).MATERIALS AND METHODS: NOV expression in CRC specimens and CRC cell lines were evaluated. The association between the clinicopathlogical factors and NOV mRNA expression of tumor tissues was assessed in 126 patients with CRC. We assessed the relationships between NOV expression and overall survival in public databases. We performed overexpression experiments in vitro.RESULTS: CRC specimens and CRC cell lines showed high NOV expression. High NOV mRNA expression was correlated with poorer overall survival and higher Union for International Cancer Control (UICC) T factor. In public databases, high NOV expression was associated with poorer prognoses. Overexpression of NOV promoted invasiveness of CRC cells.CONCLUSION: NOV may be an indicator of poor prognosis and a therapeutic target in CRC.

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