Clinical significance of gastrointestinal bleeding after living donor liver transplantation

Koichi Kimura, Toru Ikegami, Yuki Bekki, Mizuki Ninomiya, Yo Ichi Yamashita, Tomoharu Yoshizumi, Shohei Yoshiya, Yuji Soejima, Noboru Harada, Ken Shirabe, Yoshihiko Maehara

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The clinical presentations of gastrointestinal bleeding (GIB) occurring after living donor liver transplantation (LDLT) have not been fully described. We performed a retrospective analysis of 297 LDLT cases. Nineteen patients (6.4%) experienced GIB after LDLT. The etiology of GIB included bleeding at the jejunojejunostomy following hepaticojejunostomy (n = 13), peptic ulcer disease (n = 2), portal hypertensive gastropathy (n = 2), and other causes (n = 2). Hemostasis was achieved in 13 patients (68.4%) by endoscopic (n = 3), surgical (n = 1), or supportive treatments (n = 15), but not in the other six patients. Graft dysfunction (P < 0.001), hepaticojejunostomy (P = 0.01), portal vein pressure at the end of surgery >20 mmHg (P = 0.002), and operative blood loss >10 L (P = 0.004) were risk factors. One-year graft survival rate was significantly lower in patients with GIB than in patients without GIB (P < 0.001). The inhospital mortality rate was 52.6% for patients with GIB, 75.0% for patients with graft dysfunction, and 14.3% for patients without graft dysfunction (P = 0.028). Despite its infrequency after LDLT, GIB has strong correlation with graft dysfunction and inhospital mortality.

元の言語英語
ページ(範囲)705-711
ページ数7
ジャーナルTransplant International
27
発行部数7
DOI
出版物ステータス出版済み - 7 2014

All Science Journal Classification (ASJC) codes

  • Transplantation

フィンガープリント Clinical significance of gastrointestinal bleeding after living donor liver transplantation' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Kimura, K., Ikegami, T., Bekki, Y., Ninomiya, M., Yamashita, Y. I., Yoshizumi, T., Yoshiya, S., Soejima, Y., Harada, N., Shirabe, K., & Maehara, Y. (2014). Clinical significance of gastrointestinal bleeding after living donor liver transplantation. Transplant International, 27(7), 705-711. https://doi.org/10.1111/tri.12325