Clinical Significance of SIP1 and E-cadherin in Patients with Esophageal Squamous Cell Carcinoma

Rintaro Yoshida, Masaru Morita, Fumihiro Shoji, Yuichiro Nakashima, Naoko Miura, Keiji Yoshinaga, Tadashi Koga, Eriko Tokunaga, Hiroshi Saeki, Eiji Oki, Yoshinao Oda, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

抄録

Background: Epithelial-mesenchymal transition (EMT), when epithelial cells convert to mesenchymal cells, influences cancer invasion and metastasis. Smad interacting protein 1 (SIP1) is an EMT trigger, which is inversely correlated with E-cadherin in some carcinomas. To elucidate the role of SIP1 in esophageal squamous cell carcinoma (ESCC), the status of EMT and the clinicopathological features were evaluated. Methods: Immunohistochemical (IHC) analyses of 111 human ESCC tissue specimens for SIP1 and E-cadherin were performed, and the relationships between the expression and clinicopathological features were evaluated. Results: IHC analyses of esophageal tumors showed the expression of SIP1 and E-cadherin to be significantly inversely correlated. Significant correlations between the SIP1 expression and clinicopathological variables such as differentiation, depth of invasion, vascular invasion, and pathological stage were also seen. Conversely, tumors with a weak expression of E-cadherin tended to exhibit greater histological differentiation. Logistic regression analyses revealed a positive SIP1 expression, lymphatic invasion, and vascular invasion to be factors predicting lymph node (LN) metastasis. Univariate survival analyses revealed a positive SIP1 expression predicted a poorer overall survival than a negative expression. Conclusion: These results suggest that SIP1 is correlated with LN metastasis and may therefore be an independent marker for metastasis in patients with ESCC.

元の言語英語
ページ(範囲)2608-2614
ページ数7
ジャーナルAnnals of Surgical Oncology
22
発行部数8
DOI
出版物ステータス出版済み - 8 1 2015

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Smad Proteins
Cadherins
Epithelial-Mesenchymal Transition
Neoplasm Metastasis
Blood Vessels
Lymph Nodes
Neoplasms
Esophageal Squamous Cell Carcinoma
Survival Analysis
Logistic Models
Epithelial Cells
Regression Analysis
Carcinoma
Survival

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

これを引用

Clinical Significance of SIP1 and E-cadherin in Patients with Esophageal Squamous Cell Carcinoma. / Yoshida, Rintaro; Morita, Masaru; Shoji, Fumihiro; Nakashima, Yuichiro; Miura, Naoko; Yoshinaga, Keiji; Koga, Tadashi; Tokunaga, Eriko; Saeki, Hiroshi; Oki, Eiji; Oda, Yoshinao; Maehara, Yoshihiko.

:: Annals of Surgical Oncology, 巻 22, 番号 8, 01.08.2015, p. 2608-2614.

研究成果: ジャーナルへの寄稿記事

Yoshida, R, Morita, M, Shoji, F, Nakashima, Y, Miura, N, Yoshinaga, K, Koga, T, Tokunaga, E, Saeki, H, Oki, E, Oda, Y & Maehara, Y 2015, 'Clinical Significance of SIP1 and E-cadherin in Patients with Esophageal Squamous Cell Carcinoma', Annals of Surgical Oncology, 巻. 22, 番号 8, pp. 2608-2614. https://doi.org/10.1245/s10434-014-4314-1
Yoshida, Rintaro ; Morita, Masaru ; Shoji, Fumihiro ; Nakashima, Yuichiro ; Miura, Naoko ; Yoshinaga, Keiji ; Koga, Tadashi ; Tokunaga, Eriko ; Saeki, Hiroshi ; Oki, Eiji ; Oda, Yoshinao ; Maehara, Yoshihiko. / Clinical Significance of SIP1 and E-cadherin in Patients with Esophageal Squamous Cell Carcinoma. :: Annals of Surgical Oncology. 2015 ; 巻 22, 番号 8. pp. 2608-2614.
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AU - Miura, Naoko

AU - Yoshinaga, Keiji

AU - Koga, Tadashi

AU - Tokunaga, Eriko

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AU - Oki, Eiji

AU - Oda, Yoshinao

AU - Maehara, Yoshihiko

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