TY - JOUR
T1 - Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in Fukuoka Prefecture, Japan
AU - Torisu, Hiroyuki
AU - Kira, Ryutaro
AU - Ishizaki, Yoshito
AU - Sanefuji, Masafumi
AU - Yamaguchi, Yui
AU - Yasumoto, Sawa
AU - Murakami, Yoshihiko
AU - Shimono, Masayuki
AU - Nagamitsu, Shinichiro
AU - Masuzaki, Mayumi
AU - Amamoto, Masano
AU - Kondo, Rikako
AU - Uozumi, Tomohiko
AU - Aibe, Miyuki
AU - Gondo, Kenjiro
AU - Hanai, Toshio
AU - Hirose, Sinichi
AU - Matsuishi, Toyojiro
AU - Shirahata, Akira
AU - Mitsudome, Akihisa
AU - Hara, Toshiro
PY - 2010/6
Y1 - 2010/6
N2 - Acute disseminated encephalomyelitis (ADEM) has recently been studied in several countries owing to the development and wide spread use of imaging technology, but few epidemiological studies of childhood ADEM have been undertaken in Asian countries. To perform a comprehensive survey of ADEM and related diseases in Japanese children, we conducted a multicenter, population-based study on childhood ADEM, multiple sclerosis, and acute isolated transverse myelitis in Fukuoka Prefecture, Japan. We identified 26 children with ADEM, 8 with multiple sclerosis, and 4 with acute transverse myelitis during 5. years between September 1998 and August 2003. The incidence of childhood ADEM under the age of 15. years was 0.64 per 100,000 person-years, mean age at onset was 5.7. years, and male-female ratio was 2.3:1. The prevalence of childhood multiple sclerosis was 1.3 per 100,000 persons. The mean age at onset of multiple sclerosis, 9.3. years, was significantly higher than that of ADEM. Nineteen (73%) and four (15%) patients with ADEM experienced antecedent infectious illnesses and vaccinations, respectively, within 1. month before the onset. Clinical and radiological findings of ADEM revealed that the frequency of seizures, mean white blood cell counts in cerebrospinal fluid, and the frequency of subcortical lesions in Fukuoka study, seemed to be higher than those in previous non-Asian studies. These findings suggest that there are ethnic or geographical differences in the incidence and clinical features of ADEM, and that there might be potent genetic or environmental risk factors for ADEM distinct from those for multiple sclerosis.
AB - Acute disseminated encephalomyelitis (ADEM) has recently been studied in several countries owing to the development and wide spread use of imaging technology, but few epidemiological studies of childhood ADEM have been undertaken in Asian countries. To perform a comprehensive survey of ADEM and related diseases in Japanese children, we conducted a multicenter, population-based study on childhood ADEM, multiple sclerosis, and acute isolated transverse myelitis in Fukuoka Prefecture, Japan. We identified 26 children with ADEM, 8 with multiple sclerosis, and 4 with acute transverse myelitis during 5. years between September 1998 and August 2003. The incidence of childhood ADEM under the age of 15. years was 0.64 per 100,000 person-years, mean age at onset was 5.7. years, and male-female ratio was 2.3:1. The prevalence of childhood multiple sclerosis was 1.3 per 100,000 persons. The mean age at onset of multiple sclerosis, 9.3. years, was significantly higher than that of ADEM. Nineteen (73%) and four (15%) patients with ADEM experienced antecedent infectious illnesses and vaccinations, respectively, within 1. month before the onset. Clinical and radiological findings of ADEM revealed that the frequency of seizures, mean white blood cell counts in cerebrospinal fluid, and the frequency of subcortical lesions in Fukuoka study, seemed to be higher than those in previous non-Asian studies. These findings suggest that there are ethnic or geographical differences in the incidence and clinical features of ADEM, and that there might be potent genetic or environmental risk factors for ADEM distinct from those for multiple sclerosis.
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U2 - 10.1016/j.braindev.2009.10.006
DO - 10.1016/j.braindev.2009.10.006
M3 - Article
C2 - 19942388
AN - SCOPUS:77952541321
VL - 32
SP - 454
EP - 462
JO - Brain and Development
JF - Brain and Development
SN - 0387-7604
IS - 6
ER -