Clinical trial of a cancer vaccine targeting VEGF and KIF20A in advanced biliary tract cancer

Mutsunori Murahashi, Toshihisa Tsuruta, Kazunari Yamada, Yasuki Hijikata, Hisanobu Ogata, Junji Kishimoto, Sachiko Yoshimura, Tetsuro Hikichi, Yoichi Nakanishi, Kenzaburo Tani

研究成果: Contribution to journalArticle査読

抄録

Background: As the prognosis of biliary tract cancer (BTC) is extremely poor and treatment options are limited, new treatment modalities are urgently needed. We designed a phase II clinical trial to investigate the immune responses and clinical benefits of OCV-C01, an HLA-A*24:02-restricted three-peptide cancer vaccine targeting VEGFR1, VEGFR2, and KIF20A. Patients and Methods: Participants were patients with advanced BTC who had unresectable tumours and were refractory to standard chemotherapy. OCV-C01 was injected weekly until the discontinuance criteria were met. Results: Six participants, including four patients positive for HLA-A*24:02, were enrolled in this study for assessment of efficacy. Four out of six patients exhibited vaccine-specific T-cell responses to one or more of three antigens. Log-rank tests revealed that vaccine-specific T cell responses contributed significantly to overall survival. Conclusion: The cancer vaccine had positive effects on survival, indicating that this approach warrants further clinical studies.

本文言語英語
ページ(範囲)1485-1496
ページ数12
ジャーナルAnticancer research
41
3
DOI
出版ステータス出版済み - 3 2021
外部発表はい

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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