Clinical usefulness of the mDIXON Quant the method for estimation of the salivary gland fat fraction

Comparison with MR spectroscopy

Yoshitaka Kise, Toru Chikui, Yasuo Yamashita, Koji Kobayashi, Kazunori Yoshiura

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

抄録

Objective: To estimate the fat fraction (FF) in the salivary glands (SGs) by the mDIXON method and the 1H-MR spectroscopy (MRS) method, and to compare the results. Methods: 16 healthy volunteers were enrolled. mDIXON Quant and MRS (point-resolved spectroscopy: PRESS) with a single TE were employed to measure the FF in the parotid gland (PG) and submandibular gland (SMG). Multiple TEs were applied in 10 volunteers to correct for T2 decay. In addition, we assumed that the 1.3 ppm peak accounted for 60% of the total fat peak and estimated the FF (MRS all) as a gold standard. On mDIXON Quant images, volumes of interest were set on the bilateral SGs and we obtained the FF (mDIXON) of each volume of interest. Results: There was a strong correlation between the results of the mDIXON Quant method and the MRS (single TE) method (R2 = 0.960, slope = 0.900). Using PRESS with multiple TEs, there was also a strong correlation between FF (mDIXON) and FF (MRS all) (R2 = 0.963, slope = 1.18). FF (MRS all) was 24.9±12.7% in the PG and 4.5±3.0% in the SMG, while FF (mDIXON) was 29.4±16.2% in the PG and 6.4±4.7% in the SMG. There were no significant differences between the two methods, but the Bland-Altman plot showed that FF (mDIXON) was slightly larger than FF (MRS all) for small FF areas. Conclusion: The mDIXON Quant method could be clinically useful for evaluating the FF of SGs, but the absolute values need careful interpretation. Advance in knowledge: This study suggested the potential clinical usefulness of the mDIXON Quant method for the SGs.

元の言語英語
記事番号20160704
ジャーナルBritish Journal of Radiology
90
発行部数1077
DOI
出版物ステータス出版済み - 1 1 2017

Fingerprint

Salivary Glands
Magnetic Resonance Spectroscopy
Fats
Submandibular Gland
Parotid Gland
Volunteers
Spectrum Analysis
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

これを引用

Clinical usefulness of the mDIXON Quant the method for estimation of the salivary gland fat fraction : Comparison with MR spectroscopy. / Kise, Yoshitaka; Chikui, Toru; Yamashita, Yasuo; Kobayashi, Koji; Yoshiura, Kazunori.

:: British Journal of Radiology, 巻 90, 番号 1077, 20160704, 01.01.2017.

研究成果: ジャーナルへの寄稿記事

@article{3f366887a4b84a5fa18ae1fd32728d2d,
title = "Clinical usefulness of the mDIXON Quant the method for estimation of the salivary gland fat fraction: Comparison with MR spectroscopy",
abstract = "Objective: To estimate the fat fraction (FF) in the salivary glands (SGs) by the mDIXON method and the 1H-MR spectroscopy (MRS) method, and to compare the results. Methods: 16 healthy volunteers were enrolled. mDIXON Quant and MRS (point-resolved spectroscopy: PRESS) with a single TE were employed to measure the FF in the parotid gland (PG) and submandibular gland (SMG). Multiple TEs were applied in 10 volunteers to correct for T2 decay. In addition, we assumed that the 1.3 ppm peak accounted for 60{\%} of the total fat peak and estimated the FF (MRS all) as a gold standard. On mDIXON Quant images, volumes of interest were set on the bilateral SGs and we obtained the FF (mDIXON) of each volume of interest. Results: There was a strong correlation between the results of the mDIXON Quant method and the MRS (single TE) method (R2 = 0.960, slope = 0.900). Using PRESS with multiple TEs, there was also a strong correlation between FF (mDIXON) and FF (MRS all) (R2 = 0.963, slope = 1.18). FF (MRS all) was 24.9±12.7{\%} in the PG and 4.5±3.0{\%} in the SMG, while FF (mDIXON) was 29.4±16.2{\%} in the PG and 6.4±4.7{\%} in the SMG. There were no significant differences between the two methods, but the Bland-Altman plot showed that FF (mDIXON) was slightly larger than FF (MRS all) for small FF areas. Conclusion: The mDIXON Quant method could be clinically useful for evaluating the FF of SGs, but the absolute values need careful interpretation. Advance in knowledge: This study suggested the potential clinical usefulness of the mDIXON Quant method for the SGs.",
author = "Yoshitaka Kise and Toru Chikui and Yasuo Yamashita and Koji Kobayashi and Kazunori Yoshiura",
year = "2017",
month = "1",
day = "1",
doi = "10.1259/bjr.20160704",
language = "English",
volume = "90",
journal = "British Journal of Radiology",
issn = "0007-1285",
publisher = "British Institute of Radiology",
number = "1077",

}

TY - JOUR

T1 - Clinical usefulness of the mDIXON Quant the method for estimation of the salivary gland fat fraction

T2 - Comparison with MR spectroscopy

AU - Kise, Yoshitaka

AU - Chikui, Toru

AU - Yamashita, Yasuo

AU - Kobayashi, Koji

AU - Yoshiura, Kazunori

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objective: To estimate the fat fraction (FF) in the salivary glands (SGs) by the mDIXON method and the 1H-MR spectroscopy (MRS) method, and to compare the results. Methods: 16 healthy volunteers were enrolled. mDIXON Quant and MRS (point-resolved spectroscopy: PRESS) with a single TE were employed to measure the FF in the parotid gland (PG) and submandibular gland (SMG). Multiple TEs were applied in 10 volunteers to correct for T2 decay. In addition, we assumed that the 1.3 ppm peak accounted for 60% of the total fat peak and estimated the FF (MRS all) as a gold standard. On mDIXON Quant images, volumes of interest were set on the bilateral SGs and we obtained the FF (mDIXON) of each volume of interest. Results: There was a strong correlation between the results of the mDIXON Quant method and the MRS (single TE) method (R2 = 0.960, slope = 0.900). Using PRESS with multiple TEs, there was also a strong correlation between FF (mDIXON) and FF (MRS all) (R2 = 0.963, slope = 1.18). FF (MRS all) was 24.9±12.7% in the PG and 4.5±3.0% in the SMG, while FF (mDIXON) was 29.4±16.2% in the PG and 6.4±4.7% in the SMG. There were no significant differences between the two methods, but the Bland-Altman plot showed that FF (mDIXON) was slightly larger than FF (MRS all) for small FF areas. Conclusion: The mDIXON Quant method could be clinically useful for evaluating the FF of SGs, but the absolute values need careful interpretation. Advance in knowledge: This study suggested the potential clinical usefulness of the mDIXON Quant method for the SGs.

AB - Objective: To estimate the fat fraction (FF) in the salivary glands (SGs) by the mDIXON method and the 1H-MR spectroscopy (MRS) method, and to compare the results. Methods: 16 healthy volunteers were enrolled. mDIXON Quant and MRS (point-resolved spectroscopy: PRESS) with a single TE were employed to measure the FF in the parotid gland (PG) and submandibular gland (SMG). Multiple TEs were applied in 10 volunteers to correct for T2 decay. In addition, we assumed that the 1.3 ppm peak accounted for 60% of the total fat peak and estimated the FF (MRS all) as a gold standard. On mDIXON Quant images, volumes of interest were set on the bilateral SGs and we obtained the FF (mDIXON) of each volume of interest. Results: There was a strong correlation between the results of the mDIXON Quant method and the MRS (single TE) method (R2 = 0.960, slope = 0.900). Using PRESS with multiple TEs, there was also a strong correlation between FF (mDIXON) and FF (MRS all) (R2 = 0.963, slope = 1.18). FF (MRS all) was 24.9±12.7% in the PG and 4.5±3.0% in the SMG, while FF (mDIXON) was 29.4±16.2% in the PG and 6.4±4.7% in the SMG. There were no significant differences between the two methods, but the Bland-Altman plot showed that FF (mDIXON) was slightly larger than FF (MRS all) for small FF areas. Conclusion: The mDIXON Quant method could be clinically useful for evaluating the FF of SGs, but the absolute values need careful interpretation. Advance in knowledge: This study suggested the potential clinical usefulness of the mDIXON Quant method for the SGs.

UR - http://www.scopus.com/inward/record.url?scp=85028056992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028056992&partnerID=8YFLogxK

U2 - 10.1259/bjr.20160704

DO - 10.1259/bjr.20160704

M3 - Article

VL - 90

JO - British Journal of Radiology

JF - British Journal of Radiology

SN - 0007-1285

IS - 1077

M1 - 20160704

ER -