Clinicopathological characteristics of non-functioning cystic pancreatic neuroendocrine tumors

Yohei Nakashima, Ohtsuka Takao, So Nakamura, Yasuhisa Mori, Kohei Nakata, Yoshihiro Miyasaka, Kosei Ishigami, Ryota Matsuda, Yoshinao Oda, Masafumi Nakamura

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Background/objectives: The biological features of cystic pancreatic neuroendocrine tumors (PNETs) remain unclear. The aim of this study was to clarify the clinicopathological characteristics of non-functioning PNETs (NF-PNETs) with a cystic component. Methods: The medical records of 75 patients with NF-PNETs who had undergone resection in our institution were retrospectively reviewed. Clinicopathological factors were compared between PNETs with and without a cystic component. Expression of somatostatin 2 receptor (SSTR-2) was also analyzed. Results: Cystic PNETs were diagnosed in 14 patients (19%). The proportion of men was significantly higher for cystic than solid PNETs (79% vs. 44%, P < 0.05) and cystic PNETs were significantly larger than solid PNETs (25 mm vs. 17 mm, P < 0.01). However, there were no significant differences in the prevalence of lymph node metastases (14% vs. 10%, P = 0.64), hepatic metastasis (7% vs. 3%, P = 0.54), or disease-free survival rate (both 86%, P = 0.29) between PNETs with and without a cystic component. SSTR-2 expression was more frequently observed in PNETs with a cystic component than in those without (100% vs. 70%, P < 0.01). Conclusions: Although cystic PNETs were larger upon diagnosis than solid PNETs in this study, prognosis after surgical resection did not differ significantly between these types of PNET. Somatostatin receptor scintigraphy and somatostatin analogues may be more useful for diagnosing and treating cystic PNETs, respectively.

元の言語英語
ページ(範囲)50-56
ページ数7
ジャーナルPancreatology
19
発行部数1
DOI
出版物ステータス出版済み - 1 1 2019

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Neuroendocrine Tumors
Neoplasm Metastasis
Primitive Neuroectodermal Tumors
Somatostatin Receptors
Somatostatin
Radionuclide Imaging
Disease-Free Survival
Medical Records
Survival Rate

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Gastroenterology

これを引用

Clinicopathological characteristics of non-functioning cystic pancreatic neuroendocrine tumors. / Nakashima, Yohei; Takao, Ohtsuka; Nakamura, So; Mori, Yasuhisa; Nakata, Kohei; Miyasaka, Yoshihiro; Ishigami, Kosei; Matsuda, Ryota; Oda, Yoshinao; Nakamura, Masafumi.

:: Pancreatology, 巻 19, 番号 1, 01.01.2019, p. 50-56.

研究成果: ジャーナルへの寄稿記事

Nakashima, Yohei ; Takao, Ohtsuka ; Nakamura, So ; Mori, Yasuhisa ; Nakata, Kohei ; Miyasaka, Yoshihiro ; Ishigami, Kosei ; Matsuda, Ryota ; Oda, Yoshinao ; Nakamura, Masafumi. / Clinicopathological characteristics of non-functioning cystic pancreatic neuroendocrine tumors. :: Pancreatology. 2019 ; 巻 19, 番号 1. pp. 50-56.
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title = "Clinicopathological characteristics of non-functioning cystic pancreatic neuroendocrine tumors",
abstract = "Background/objectives: The biological features of cystic pancreatic neuroendocrine tumors (PNETs) remain unclear. The aim of this study was to clarify the clinicopathological characteristics of non-functioning PNETs (NF-PNETs) with a cystic component. Methods: The medical records of 75 patients with NF-PNETs who had undergone resection in our institution were retrospectively reviewed. Clinicopathological factors were compared between PNETs with and without a cystic component. Expression of somatostatin 2 receptor (SSTR-2) was also analyzed. Results: Cystic PNETs were diagnosed in 14 patients (19{\%}). The proportion of men was significantly higher for cystic than solid PNETs (79{\%} vs. 44{\%}, P < 0.05) and cystic PNETs were significantly larger than solid PNETs (25 mm vs. 17 mm, P < 0.01). However, there were no significant differences in the prevalence of lymph node metastases (14{\%} vs. 10{\%}, P = 0.64), hepatic metastasis (7{\%} vs. 3{\%}, P = 0.54), or disease-free survival rate (both 86{\%}, P = 0.29) between PNETs with and without a cystic component. SSTR-2 expression was more frequently observed in PNETs with a cystic component than in those without (100{\%} vs. 70{\%}, P < 0.01). Conclusions: Although cystic PNETs were larger upon diagnosis than solid PNETs in this study, prognosis after surgical resection did not differ significantly between these types of PNET. Somatostatin receptor scintigraphy and somatostatin analogues may be more useful for diagnosing and treating cystic PNETs, respectively.",
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T1 - Clinicopathological characteristics of non-functioning cystic pancreatic neuroendocrine tumors

AU - Nakashima, Yohei

AU - Takao, Ohtsuka

AU - Nakamura, So

AU - Mori, Yasuhisa

AU - Nakata, Kohei

AU - Miyasaka, Yoshihiro

AU - Ishigami, Kosei

AU - Matsuda, Ryota

AU - Oda, Yoshinao

AU - Nakamura, Masafumi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background/objectives: The biological features of cystic pancreatic neuroendocrine tumors (PNETs) remain unclear. The aim of this study was to clarify the clinicopathological characteristics of non-functioning PNETs (NF-PNETs) with a cystic component. Methods: The medical records of 75 patients with NF-PNETs who had undergone resection in our institution were retrospectively reviewed. Clinicopathological factors were compared between PNETs with and without a cystic component. Expression of somatostatin 2 receptor (SSTR-2) was also analyzed. Results: Cystic PNETs were diagnosed in 14 patients (19%). The proportion of men was significantly higher for cystic than solid PNETs (79% vs. 44%, P < 0.05) and cystic PNETs were significantly larger than solid PNETs (25 mm vs. 17 mm, P < 0.01). However, there were no significant differences in the prevalence of lymph node metastases (14% vs. 10%, P = 0.64), hepatic metastasis (7% vs. 3%, P = 0.54), or disease-free survival rate (both 86%, P = 0.29) between PNETs with and without a cystic component. SSTR-2 expression was more frequently observed in PNETs with a cystic component than in those without (100% vs. 70%, P < 0.01). Conclusions: Although cystic PNETs were larger upon diagnosis than solid PNETs in this study, prognosis after surgical resection did not differ significantly between these types of PNET. Somatostatin receptor scintigraphy and somatostatin analogues may be more useful for diagnosing and treating cystic PNETs, respectively.

AB - Background/objectives: The biological features of cystic pancreatic neuroendocrine tumors (PNETs) remain unclear. The aim of this study was to clarify the clinicopathological characteristics of non-functioning PNETs (NF-PNETs) with a cystic component. Methods: The medical records of 75 patients with NF-PNETs who had undergone resection in our institution were retrospectively reviewed. Clinicopathological factors were compared between PNETs with and without a cystic component. Expression of somatostatin 2 receptor (SSTR-2) was also analyzed. Results: Cystic PNETs were diagnosed in 14 patients (19%). The proportion of men was significantly higher for cystic than solid PNETs (79% vs. 44%, P < 0.05) and cystic PNETs were significantly larger than solid PNETs (25 mm vs. 17 mm, P < 0.01). However, there were no significant differences in the prevalence of lymph node metastases (14% vs. 10%, P = 0.64), hepatic metastasis (7% vs. 3%, P = 0.54), or disease-free survival rate (both 86%, P = 0.29) between PNETs with and without a cystic component. SSTR-2 expression was more frequently observed in PNETs with a cystic component than in those without (100% vs. 70%, P < 0.01). Conclusions: Although cystic PNETs were larger upon diagnosis than solid PNETs in this study, prognosis after surgical resection did not differ significantly between these types of PNET. Somatostatin receptor scintigraphy and somatostatin analogues may be more useful for diagnosing and treating cystic PNETs, respectively.

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DO - 10.1016/j.pan.2018.11.010

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EP - 56

JO - Pancreatology

JF - Pancreatology

SN - 1424-3903

IS - 1

ER -