Clinicopathological features of HCV-positive splenic diffuse large B cell lymphoma

Joji Shimono, Hiroaki Miyoshi, Fumiko Arakawa, Kyohei Yamada, Takeshi Sugio, Kohta Miyawaki, Tetsuya Eto, Takuto Miyagishima, Koji Kato, Koji Nagafuji, Koichi Akashi, Takanori Teshima, Koichi Ohshima

研究成果: ジャーナルへの寄稿記事

抄録

The hepatitis C virus (HCV) is a single-stranded RNA virus which is thought to be involved in the onset of B cell lymphoma. HCV-positive diffuse large B cell lymphoma (DLBCL) has been reported to clinically manifest in extranodal lesions (e.g., in the liver, spleen, and stomach). Here, we investigated HCV-positive and -negative primary splenic DLBCL (p-spDLBCL) and non-primary splenic DLBCL (ordinary DLBCL). Furthermore, to examine HCV lymphomagenesis, RNA in situ hybridization (ISH), RT-PCR (reverse-transcription polymerase chain reaction), and NS3 immunostaining of HCV viral nonstructural proteins were performed. HCV-positive p-spDLBCL patients presented fewer B symptoms (asymptomatic) and better performance status, with elevated presence of splenic macronodular lesions and more germinal center B cell (GCB) sub-group cases than HCV-negative p-spDLBCL patients. However, HCV-positive ordinary DLBCL patients were found to have more non-GCB sub-group cases than HCV-negative ordinary DLBCL patients. HCV-positive DLBCL patients showed 20.6% (7/34) NS3 positivity, 16.7% (1/6) HCV-RNA in situ positivity, and 22.2% (2/9) detection of HCV-RNA in tumor tissue by RT-PCR. Splenic samples were found to have a higher frequency of HCV detection than lymph node samples, thus suggesting that HCV may be closely related to lymphomagenesis, especially in splenic lymphoma.

元の言語英語
ページ(範囲)1197-1207
ページ数11
ジャーナルAnnals of Hematology
98
発行部数5
DOI
出版物ステータス出版済み - 5 1 2019

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Lymphoma, Large B-Cell, Diffuse
Hepacivirus
B-Cell Lymphoma
RNA
Reverse Transcription
B-Lymphocytes
Viral Nonstructural Proteins
Polymerase Chain Reaction
Germinal Center
RNA Viruses
In Situ Hybridization
Lymphoma
Stomach

All Science Journal Classification (ASJC) codes

  • Hematology

これを引用

Shimono, J., Miyoshi, H., Arakawa, F., Yamada, K., Sugio, T., Miyawaki, K., ... Ohshima, K. (2019). Clinicopathological features of HCV-positive splenic diffuse large B cell lymphoma. Annals of Hematology, 98(5), 1197-1207. https://doi.org/10.1007/s00277-019-03628-8

Clinicopathological features of HCV-positive splenic diffuse large B cell lymphoma. / Shimono, Joji; Miyoshi, Hiroaki; Arakawa, Fumiko; Yamada, Kyohei; Sugio, Takeshi; Miyawaki, Kohta; Eto, Tetsuya; Miyagishima, Takuto; Kato, Koji; Nagafuji, Koji; Akashi, Koichi; Teshima, Takanori; Ohshima, Koichi.

:: Annals of Hematology, 巻 98, 番号 5, 01.05.2019, p. 1197-1207.

研究成果: ジャーナルへの寄稿記事

Shimono, J, Miyoshi, H, Arakawa, F, Yamada, K, Sugio, T, Miyawaki, K, Eto, T, Miyagishima, T, Kato, K, Nagafuji, K, Akashi, K, Teshima, T & Ohshima, K 2019, 'Clinicopathological features of HCV-positive splenic diffuse large B cell lymphoma', Annals of Hematology, 巻. 98, 番号 5, pp. 1197-1207. https://doi.org/10.1007/s00277-019-03628-8
Shimono J, Miyoshi H, Arakawa F, Yamada K, Sugio T, Miyawaki K その他. Clinicopathological features of HCV-positive splenic diffuse large B cell lymphoma. Annals of Hematology. 2019 5 1;98(5):1197-1207. https://doi.org/10.1007/s00277-019-03628-8
Shimono, Joji ; Miyoshi, Hiroaki ; Arakawa, Fumiko ; Yamada, Kyohei ; Sugio, Takeshi ; Miyawaki, Kohta ; Eto, Tetsuya ; Miyagishima, Takuto ; Kato, Koji ; Nagafuji, Koji ; Akashi, Koichi ; Teshima, Takanori ; Ohshima, Koichi. / Clinicopathological features of HCV-positive splenic diffuse large B cell lymphoma. :: Annals of Hematology. 2019 ; 巻 98, 番号 5. pp. 1197-1207.
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abstract = "The hepatitis C virus (HCV) is a single-stranded RNA virus which is thought to be involved in the onset of B cell lymphoma. HCV-positive diffuse large B cell lymphoma (DLBCL) has been reported to clinically manifest in extranodal lesions (e.g., in the liver, spleen, and stomach). Here, we investigated HCV-positive and -negative primary splenic DLBCL (p-spDLBCL) and non-primary splenic DLBCL (ordinary DLBCL). Furthermore, to examine HCV lymphomagenesis, RNA in situ hybridization (ISH), RT-PCR (reverse-transcription polymerase chain reaction), and NS3 immunostaining of HCV viral nonstructural proteins were performed. HCV-positive p-spDLBCL patients presented fewer B symptoms (asymptomatic) and better performance status, with elevated presence of splenic macronodular lesions and more germinal center B cell (GCB) sub-group cases than HCV-negative p-spDLBCL patients. However, HCV-positive ordinary DLBCL patients were found to have more non-GCB sub-group cases than HCV-negative ordinary DLBCL patients. HCV-positive DLBCL patients showed 20.6{\%} (7/34) NS3 positivity, 16.7{\%} (1/6) HCV-RNA in situ positivity, and 22.2{\%} (2/9) detection of HCV-RNA in tumor tissue by RT-PCR. Splenic samples were found to have a higher frequency of HCV detection than lymph node samples, thus suggesting that HCV may be closely related to lymphomagenesis, especially in splenic lymphoma.",
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AU - Sugio, Takeshi

AU - Miyawaki, Kohta

AU - Eto, Tetsuya

AU - Miyagishima, Takuto

AU - Kato, Koji

AU - Nagafuji, Koji

AU - Akashi, Koichi

AU - Teshima, Takanori

AU - Ohshima, Koichi

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