Clonal expansion but lack of subsequent clonal deletion of bacterial superantigen-reactive T cells in murine retroviral infection

Yoshiyasu Aoki, Kenji Hiromatsu, Jun Usami, Masahiko Makino, Hideo Igarashi, Jun Ogasawara, Shigekazu Nagata, Yasunobu Yoshikai

    研究成果: Contribution to journalArticle査読

    17 被引用数 (Scopus)

    抄録

    Several studies have suggested that activation-induced apoptosis of Ag- specific CD4+ T cells leads to depletion of this subset during HIV infection. The bacterial superantigen, staphylococcal enterotoxin A (SEA), is known to induce activation-induced apoptosis in the TCR Vβ-bearing CD4+ T cells in the periphery after clonal expansion of these cells. The murine retroviral model of AIDS (MAIDS), which is induced by LP-BM5 murine leukemia virus, shares many common features with HIV infection in humans, except that CD4+ T cells increase progressively in susceptible strains. In this study, we challenged SEA to MAIDS mice and examined whether this retrovirus affects the fate of the SEA-reactive CD4+ T cells in vivo. At 4 wk post-infection with LP-BM5 murine leukemia virus, clonal expansion and subsequent deletion of SEA-reactive CD4+Vβ3+ T cells occurred normally after SEA administration, whereas in vitro proliferative responses were severely impaired. At 8 wk postinfection, the in vivo expansion of CD4+Vβ3+ T cells was evident, but not followed by clonal deletion, as late as 14 days after SEA administration. This expanding subset in the infected mice expressed the Fas Ag in the same amount as the same subset in uninfected controls. These findings suggest that activation-induced apoptosis of superantigen-reactive CD4+ T cells is interfered with in vivo during the course of MAIDS, which is not attributable to underexpression of the Fas Ag by the CD4+ T cells.

    本文言語英語
    ページ(範囲)3611-3621
    ページ数11
    ジャーナルJournal of Immunology
    153
    8
    出版ステータス出版済み - 10 15 1994

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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