Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS

Yasunobu Yoshikai; Hiroyuki Kidokoro; Keiko Kimura; Yoshiyasu Aoki; Masahiko Makino; Kenji Hiromatsu

doi:10.1128/jvi.71.1.746-749.1997

Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS

Yasunobu Yoshikai, Hiroyuki Kidokoro, Keiko Kimura, Yoshiyasu Aoki, Masahiko Makino, Kenji Hiromatsu

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

3 被引用数 (Scopus)

抄録

Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.

本文言語	英語
ページ（範囲）	746-749
ページ数	4
ジャーナル	Journal of virology
巻	71
号	1
DOI	https://doi.org/10.1128/jvi.71.1.746-749.1997
出版ステータス	出版済み - 1997

!!!All Science Journal Classification (ASJC) codes

微生物学
免疫学
昆虫科学
ウイルス学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1128/jvi.71.1.746-749.1997

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title = "Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS",

abstract = "Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.",

author = "Yasunobu Yoshikai and Hiroyuki Kidokoro and Keiko Kimura and Yoshiyasu Aoki and Masahiko Makino and Kenji Hiromatsu",

year = "1997",

doi = "10.1128/jvi.71.1.746-749.1997",

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T1 - Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS

AU - Yoshikai, Yasunobu

AU - Kidokoro, Hiroyuki

AU - Kimura, Keiko

AU - Aoki, Yoshiyasu

AU - Makino, Masahiko

AU - Hiromatsu, Kenji

PY - 1997

Y1 - 1997

N2 - Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.

AB - Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.

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U2 - 10.1128/jvi.71.1.746-749.1997

DO - 10.1128/jvi.71.1.746-749.1997

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AN - SCOPUS:0031060454

VL - 71

SP - 746

EP - 749

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 1

ER -

Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS

抄録

!!!All Science Journal Classification (ASJC) codes

UN SDG

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