Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS

Yasunobu Yoshikai, Hiroyuki Kidokoro, Keiko Kimura, Yoshiyasu Aoki, Masahiko Makino, Kenji Hiromatsu

    研究成果: ジャーナルへの寄稿 › 記事

    3 引用 (Scopus)

    抄録

    Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.

    元の言語英語
    ページ（範囲）746-749
    ページ数4
    ジャーナルJournal of Virology
    巻71
    発行部数1
    出版物ステータス出版済み - 1 1 1997

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    superantigens
    Superantigens
    Tacrolimus
    Murine Acquired Immunodeficiency Syndrome
    Acquired Immunodeficiency Syndrome
    T-lymphocytes
    T-Lymphocytes
    mice
    enterotoxins
    Murine Leukemia Viruses
    Subcutaneous Injections
    Murine leukemia virus
    Body Weight
    subcutaneous injection
    Injections
    Infection
    injection
    body weight
    Staphylococcal enterotoxin A
    infection

    All Science Journal Classification (ASJC) codes

    • Microbiology
    • Immunology
    • Insect Science
    • Virology

    これを引用

    Yoshikai, Y., Kidokoro, H., Kimura, K., Aoki, Y., Makino, M., & Hiromatsu, K. (1997). Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS. Journal of Virology, 71(1), 746-749.

    Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS. / Yoshikai, Yasunobu; Kidokoro, Hiroyuki; Kimura, Keiko; Aoki, Yoshiyasu; Makino, Masahiko; Hiromatsu, Kenji.

    ：: Journal of Virology, 巻 71, 番号 1, 01.01.1997, p. 746-749.

    研究成果: ジャーナルへの寄稿 › 記事

    Yoshikai, Y, Kidokoro, H, Kimura, K, Aoki, Y, Makino, M & Hiromatsu, K 1997, 'Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS', Journal of Virology, 巻. 71, 番号 1, pp. 746-749.
    Yoshikai Y, Kidokoro H, Kimura K, Aoki Y, Makino M, Hiromatsu K. Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS. Journal of Virology. 1997 1 1;71(1):746-749.
    Yoshikai, Yasunobu ; Kidokoro, Hiroyuki ; Kimura, Keiko ; Aoki, Yoshiyasu ; Makino, Masahiko ; Hiromatsu, Kenji. / Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS. ：: Journal of Virology. 1997 ; 巻 71, 番号 1. pp. 746-749.
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    abstract = "Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.",
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