Close association between oral Candida species and oral mucosal disorders in patients with xerostomia

S. Shinozaki, Masafumi Moriyama, J. N. Hayashida, A. Tanaka, takashi maehara, S. Ieda, Seiji Nakamura

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

抄録

Objective: Heightened interest in oral health has lead to an increase in patients complaining of xerostomia, which is associated with various oral mucosal disorders. In this study, we investigated the relationship between Candida species and oral mucosal disorders in patients with xerostomia. Subjects and Methods: We evaluated whole salivary flow rate and presence of oral mucosal disorders in 48 patients with xerostomia and 15 healthy controls. The number of Candida species was measured as colony-forming units after propagation on selective medium. Identification of Candida at the species level was carried out by polymerase chain reaction and restriction fragment length polymorphism analysis. We then examined the relationship between Candida species and oral mucosal symptoms. Results: Compared with controls, patients with xerostomia exhibited significantly decreased whole salivary flow rate, increased rate of oral mucosal symptoms, and higher numbers of Candida. Salivary flow rate negatively correlated with the number Candida. Among patients with oral candidiasis, Candida albicanswas isolated from the tongue mucosa and Candida glabratawas isolated from the angle of the mouth. Conclusion: These results suggest that particular Candida species are involved in the pathogenesis of oral mucosal disorders in patients with xerostomia.

元の言語英語
ページ(範囲)667-672
ページ数6
ジャーナルOral Diseases
18
発行部数7
DOI
出版物ステータス出版済み - 10 2012

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Xerostomia
Candida
Oral Candidiasis
Oral Health
Tongue
Restriction Fragment Length Polymorphisms
Mouth
Mucous Membrane
Stem Cells
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Dentistry(all)
  • Otorhinolaryngology

これを引用

Close association between oral Candida species and oral mucosal disorders in patients with xerostomia. / Shinozaki, S.; Moriyama, Masafumi; Hayashida, J. N.; Tanaka, A.; maehara, takashi; Ieda, S.; Nakamura, Seiji.

:: Oral Diseases, 巻 18, 番号 7, 10.2012, p. 667-672.

研究成果: ジャーナルへの寄稿記事

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AU - maehara, takashi

AU - Ieda, S.

AU - Nakamura, Seiji

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N2 - Objective: Heightened interest in oral health has lead to an increase in patients complaining of xerostomia, which is associated with various oral mucosal disorders. In this study, we investigated the relationship between Candida species and oral mucosal disorders in patients with xerostomia. Subjects and Methods: We evaluated whole salivary flow rate and presence of oral mucosal disorders in 48 patients with xerostomia and 15 healthy controls. The number of Candida species was measured as colony-forming units after propagation on selective medium. Identification of Candida at the species level was carried out by polymerase chain reaction and restriction fragment length polymorphism analysis. We then examined the relationship between Candida species and oral mucosal symptoms. Results: Compared with controls, patients with xerostomia exhibited significantly decreased whole salivary flow rate, increased rate of oral mucosal symptoms, and higher numbers of Candida. Salivary flow rate negatively correlated with the number Candida. Among patients with oral candidiasis, Candida albicanswas isolated from the tongue mucosa and Candida glabratawas isolated from the angle of the mouth. Conclusion: These results suggest that particular Candida species are involved in the pathogenesis of oral mucosal disorders in patients with xerostomia.

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