Close link between development and function of gamma-delta T cells

Kensuke Shibata

    研究成果: Contribution to journalReview article査読

    12 被引用数 (Scopus)

    抄録

    Murine γδ T cells develop as the first T-cell lineage within the fetal thymus and disproportionately localize in mucosal tissues such as lung, skin, uterus, and intestine of adult mice. These unique developmental features and distribution patterns of γδ T cells enable rapid functioning against various insults from pathogens γδ T cells are also able to respond to local inflammation and consequently regulate the pathogenesis of autoimmune disorders and development of tumors in mice and humans. Hence, it is clinically important to understand the mechanisms that regulate γδ T cell functions. Recent evidence has shown that generations of effector γδ T cell subsets producing IFN-γ, IL-4, and IL-17 are programmed in the murine thymus before their migration to peripheral tissues. This review outlines our current understanding of the development and function of γδ T cells as they influence both innate and acquired immunity.

    本文言語英語
    ページ(範囲)217-227
    ページ数11
    ジャーナルMICROBIOLOGY and IMMUNOLOGY
    56
    4
    DOI
    出版ステータス出版済み - 4 2012

    All Science Journal Classification (ASJC) codes

    • 微生物学
    • 免疫学
    • ウイルス学

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