Close link between development and function of gamma-delta T cells

Kensuke Shibata

    研究成果: ジャーナルへの寄稿評論記事

    12 引用 (Scopus)

    抄録

    Murine γδ T cells develop as the first T-cell lineage within the fetal thymus and disproportionately localize in mucosal tissues such as lung, skin, uterus, and intestine of adult mice. These unique developmental features and distribution patterns of γδ T cells enable rapid functioning against various insults from pathogens γδ T cells are also able to respond to local inflammation and consequently regulate the pathogenesis of autoimmune disorders and development of tumors in mice and humans. Hence, it is clinically important to understand the mechanisms that regulate γδ T cell functions. Recent evidence has shown that generations of effector γδ T cell subsets producing IFN-γ, IL-4, and IL-17 are programmed in the murine thymus before their migration to peripheral tissues. This review outlines our current understanding of the development and function of γδ T cells as they influence both innate and acquired immunity.

    元の言語英語
    ページ(範囲)217-227
    ページ数11
    ジャーナルMICROBIOLOGY and IMMUNOLOGY
    56
    発行部数4
    DOI
    出版物ステータス出版済み - 4 1 2012

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    Somatostatin-Secreting Cells
    T-Lymphocytes
    Thymus Gland
    Interleukin-17
    T-Lymphocyte Subsets
    Adaptive Immunity
    Cell Lineage
    Innate Immunity
    Interleukin-4
    Uterus
    Intestines
    Mucous Membrane
    Inflammation
    Lung
    Skin
    Neoplasms

    All Science Journal Classification (ASJC) codes

    • Immunology
    • Microbiology
    • Virology

    これを引用

    Close link between development and function of gamma-delta T cells. / Shibata, Kensuke.

    :: MICROBIOLOGY and IMMUNOLOGY, 巻 56, 番号 4, 01.04.2012, p. 217-227.

    研究成果: ジャーナルへの寄稿評論記事

    Shibata, Kensuke. / Close link between development and function of gamma-delta T cells. :: MICROBIOLOGY and IMMUNOLOGY. 2012 ; 巻 56, 番号 4. pp. 217-227.
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