抄録
Murine γδ T cells develop as the first T-cell lineage within the fetal thymus and disproportionately localize in mucosal tissues such as lung, skin, uterus, and intestine of adult mice. These unique developmental features and distribution patterns of γδ T cells enable rapid functioning against various insults from pathogens γδ T cells are also able to respond to local inflammation and consequently regulate the pathogenesis of autoimmune disorders and development of tumors in mice and humans. Hence, it is clinically important to understand the mechanisms that regulate γδ T cell functions. Recent evidence has shown that generations of effector γδ T cell subsets producing IFN-γ, IL-4, and IL-17 are programmed in the murine thymus before their migration to peripheral tissues. This review outlines our current understanding of the development and function of γδ T cells as they influence both innate and acquired immunity.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 217-227 |
| ページ数 | 11 |
| ジャーナル | MICROBIOLOGY and IMMUNOLOGY |
| 巻 | 56 |
| 発行部数 | 4 |
| DOI | |
| 出版物ステータス | 出版済み - 4 1 2012 |
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All Science Journal Classification (ASJC) codes
- Immunology
- Microbiology
- Virology
これを引用
Close link between development and function of gamma-delta T cells. / Shibata, Kensuke.
：: MICROBIOLOGY and IMMUNOLOGY, 巻 56, 番号 4, 01.04.2012, p. 217-227.研究成果: ジャーナルへの寄稿 › 評論記事
}
TY - JOUR
T1 - Close link between development and function of gamma-delta T cells
AU - Shibata, Kensuke
PY - 2012/4/1
Y1 - 2012/4/1
N2 - Murine γδ T cells develop as the first T-cell lineage within the fetal thymus and disproportionately localize in mucosal tissues such as lung, skin, uterus, and intestine of adult mice. These unique developmental features and distribution patterns of γδ T cells enable rapid functioning against various insults from pathogens γδ T cells are also able to respond to local inflammation and consequently regulate the pathogenesis of autoimmune disorders and development of tumors in mice and humans. Hence, it is clinically important to understand the mechanisms that regulate γδ T cell functions. Recent evidence has shown that generations of effector γδ T cell subsets producing IFN-γ, IL-4, and IL-17 are programmed in the murine thymus before their migration to peripheral tissues. This review outlines our current understanding of the development and function of γδ T cells as they influence both innate and acquired immunity.
AB - Murine γδ T cells develop as the first T-cell lineage within the fetal thymus and disproportionately localize in mucosal tissues such as lung, skin, uterus, and intestine of adult mice. These unique developmental features and distribution patterns of γδ T cells enable rapid functioning against various insults from pathogens γδ T cells are also able to respond to local inflammation and consequently regulate the pathogenesis of autoimmune disorders and development of tumors in mice and humans. Hence, it is clinically important to understand the mechanisms that regulate γδ T cell functions. Recent evidence has shown that generations of effector γδ T cell subsets producing IFN-γ, IL-4, and IL-17 are programmed in the murine thymus before their migration to peripheral tissues. This review outlines our current understanding of the development and function of γδ T cells as they influence both innate and acquired immunity.
UR - http://www.scopus.com/inward/record.url?scp=84859826692&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859826692&partnerID=8YFLogxK
U2 - 10.1111/j.1348-0421.2012.00435.x
DO - 10.1111/j.1348-0421.2012.00435.x
M3 - Review article
C2 - 22300310
AN - SCOPUS:84859826692
VL - 56
SP - 217
EP - 227
JO - Microbiology and Immunology
JF - Microbiology and Immunology
SN - 0385-5600
IS - 4
ER -