CNS high-grade neuroepithelial tumor with BCOR internal tandem duplication: a comparison with its counterparts in the kidney and soft tissue

Yuka Yoshida, Sumihito Nobusawa, Satoshi Nakata, Mitsutoshi Nakada, Yoshiki Arakawa, Yohei Mineharu, Yasuo Sugita, Takako Yoshioka, Asuka Araki, Yuichiro Sato, Hideo Takeshima, Masahiko Okada, Akira Nishi, Tatsuya Yamazaki, Kenichi Kohashi, Yoshinao Oda, Junko Hirato, Hideaki Yokoo

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

抄録

Central nervous system high-grade neuroepithelial tumors with BCOR alteration (CNS HGNET-BCOR) are a recently reported rare entity, identified as a small fraction of tumors previously institutionally diagnosed as so-called CNS primitive neuroectodermal tumors. Their genetic characteristic is a somatic internal tandem duplication in the 3′ end of BCOR (BCOR ITD), which has also been found in clear cell sarcomas of the kidney (CCSK) and soft tissue undifferentiated round cell sarcomas/primitive myxoid mesenchymal tumors of infancy (URCS/PMMTI), and these BCOR ITD-positive tumors have been reported to share similar pathological features. In this study, we performed a clinicopathological and molecular analysis of six cases of CNS HGNET-BCOR, and compared them with their counterparts in the kidney and soft tissue. Although these tumors had histologically similar structural patterns and characteristic monotonous nuclei with fine chromatin, CNS HGNET-BCOR exhibited glial cell morphology, ependymoma-like perivascular pseudorosettes and palisading necrosis, whereas these features were not evident in CCSK or URCS/PMMTI. Immunohistochemically, diffuse staining of Olig2 with a mixture of varying degrees of intensity, and only focal staining of GFAP, S-100 protein and synaptophysin were observed in CNS HGNET-BCOR, whereas these common neuroepithelial markers were negative in CCSK and URCS/PMMTI. Therefore, although CNS HGNET-BCOR, CCSK and URCS/PMMTI may constitute a group of BCOR ITD-positive tumors, only CNS HGNET-BCOR has histological features suggestive of glial differentiation. In conclusion, we think CNS HGNET-BCOR are a certain type of neuroepithelial tumor relatively close to glioma, not CCSK or URCS/PMMTI occurring in the CNS.

元の言語英語
ページ(範囲)710-720
ページ数11
ジャーナルBrain Pathology
28
発行部数5
DOI
出版物ステータス出版済み - 9 2018

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Neuroepithelial Neoplasms
Clear Cell Sarcoma
Kidney
Sarcoma
Central Nervous System
Neoplasms
Neuroglia
Staining and Labeling
Primitive Neuroectodermal Tumors
Ependymoma
Central Nervous System Neoplasms
Synaptophysin
S100 Proteins
Glioma
Chromatin
Necrosis

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Neuroscience(all)
  • Clinical Neurology

これを引用

CNS high-grade neuroepithelial tumor with BCOR internal tandem duplication : a comparison with its counterparts in the kidney and soft tissue. / Yoshida, Yuka; Nobusawa, Sumihito; Nakata, Satoshi; Nakada, Mitsutoshi; Arakawa, Yoshiki; Mineharu, Yohei; Sugita, Yasuo; Yoshioka, Takako; Araki, Asuka; Sato, Yuichiro; Takeshima, Hideo; Okada, Masahiko; Nishi, Akira; Yamazaki, Tatsuya; Kohashi, Kenichi; Oda, Yoshinao; Hirato, Junko; Yokoo, Hideaki.

:: Brain Pathology, 巻 28, 番号 5, 09.2018, p. 710-720.

研究成果: ジャーナルへの寄稿記事

Yoshida, Y, Nobusawa, S, Nakata, S, Nakada, M, Arakawa, Y, Mineharu, Y, Sugita, Y, Yoshioka, T, Araki, A, Sato, Y, Takeshima, H, Okada, M, Nishi, A, Yamazaki, T, Kohashi, K, Oda, Y, Hirato, J & Yokoo, H 2018, 'CNS high-grade neuroepithelial tumor with BCOR internal tandem duplication: a comparison with its counterparts in the kidney and soft tissue', Brain Pathology, 巻. 28, 番号 5, pp. 710-720. https://doi.org/10.1111/bpa.12585
Yoshida, Yuka ; Nobusawa, Sumihito ; Nakata, Satoshi ; Nakada, Mitsutoshi ; Arakawa, Yoshiki ; Mineharu, Yohei ; Sugita, Yasuo ; Yoshioka, Takako ; Araki, Asuka ; Sato, Yuichiro ; Takeshima, Hideo ; Okada, Masahiko ; Nishi, Akira ; Yamazaki, Tatsuya ; Kohashi, Kenichi ; Oda, Yoshinao ; Hirato, Junko ; Yokoo, Hideaki. / CNS high-grade neuroepithelial tumor with BCOR internal tandem duplication : a comparison with its counterparts in the kidney and soft tissue. :: Brain Pathology. 2018 ; 巻 28, 番号 5. pp. 710-720.
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title = "CNS high-grade neuroepithelial tumor with BCOR internal tandem duplication: a comparison with its counterparts in the kidney and soft tissue",
abstract = "Central nervous system high-grade neuroepithelial tumors with BCOR alteration (CNS HGNET-BCOR) are a recently reported rare entity, identified as a small fraction of tumors previously institutionally diagnosed as so-called CNS primitive neuroectodermal tumors. Their genetic characteristic is a somatic internal tandem duplication in the 3′ end of BCOR (BCOR ITD), which has also been found in clear cell sarcomas of the kidney (CCSK) and soft tissue undifferentiated round cell sarcomas/primitive myxoid mesenchymal tumors of infancy (URCS/PMMTI), and these BCOR ITD-positive tumors have been reported to share similar pathological features. In this study, we performed a clinicopathological and molecular analysis of six cases of CNS HGNET-BCOR, and compared them with their counterparts in the kidney and soft tissue. Although these tumors had histologically similar structural patterns and characteristic monotonous nuclei with fine chromatin, CNS HGNET-BCOR exhibited glial cell morphology, ependymoma-like perivascular pseudorosettes and palisading necrosis, whereas these features were not evident in CCSK or URCS/PMMTI. Immunohistochemically, diffuse staining of Olig2 with a mixture of varying degrees of intensity, and only focal staining of GFAP, S-100 protein and synaptophysin were observed in CNS HGNET-BCOR, whereas these common neuroepithelial markers were negative in CCSK and URCS/PMMTI. Therefore, although CNS HGNET-BCOR, CCSK and URCS/PMMTI may constitute a group of BCOR ITD-positive tumors, only CNS HGNET-BCOR has histological features suggestive of glial differentiation. In conclusion, we think CNS HGNET-BCOR are a certain type of neuroepithelial tumor relatively close to glioma, not CCSK or URCS/PMMTI occurring in the CNS.",
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T2 - a comparison with its counterparts in the kidney and soft tissue

AU - Yoshida, Yuka

AU - Nobusawa, Sumihito

AU - Nakata, Satoshi

AU - Nakada, Mitsutoshi

AU - Arakawa, Yoshiki

AU - Mineharu, Yohei

AU - Sugita, Yasuo

AU - Yoshioka, Takako

AU - Araki, Asuka

AU - Sato, Yuichiro

AU - Takeshima, Hideo

AU - Okada, Masahiko

AU - Nishi, Akira

AU - Yamazaki, Tatsuya

AU - Kohashi, Kenichi

AU - Oda, Yoshinao

AU - Hirato, Junko

AU - Yokoo, Hideaki

PY - 2018/9

Y1 - 2018/9

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