Co-occurrence and high-performance liquid chromatographic separation of the glycosides of rhodeasapogenin and its analogs which differ in the f-ring structure

Kazumoto Miyahara, Keiko Kudo, Toshio Kawasaki

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

抄録

Two spirostanol glycosides (steroid saponins) R-3 (I) and R-8 (II), which were regarded, respectively, as pure 1-0-α-L-rhamnopyranosyl-(1-2)-β-D-xylopyranoside and 3-0-β-D-glucopyranoside of rhodeasapogenin(25S) (III), were shown by 13C-NMR to be accompanied by the corresponding glycosides of isorhodeasapogenin(25R) (IV) and conva-llamarogenin(Δ25(27)) (V). Qualitative and preparative separation by HPLC of the components of I and II were studied and successfully achieved by a combination of two methods. They consisted equally of not three but four compounds, which were isolated in the pure state. Three of them were identified as the glycosides of III (major), IV and V, while the fourth was considered to have the same sugar moiety as I or II combined with a new aglycone different from III - V in the F-ring structure. The methods were applied also to some commonly known sterod saponins.

元の言語英語
ページ(範囲)348-351
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
31
発行部数1
DOI
出版物ステータス出版済み - 1 1 1983

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Glycosides
Saponins
Spirostans
Liquids
Sugars
Steroids
High Pressure Liquid Chromatography
Nuclear magnetic resonance

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

これを引用

Co-occurrence and high-performance liquid chromatographic separation of the glycosides of rhodeasapogenin and its analogs which differ in the f-ring structure. / Miyahara, Kazumoto; Kudo, Keiko; Kawasaki, Toshio.

:: Chemical and Pharmaceutical Bulletin, 巻 31, 番号 1, 01.01.1983, p. 348-351.

研究成果: ジャーナルへの寄稿記事

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