Co-occurrence and high-performance liquid chromatographic separation of the glycosides of rhodeasapogenin and its analogs which differ in the f-ring structure

Kazumoto Miyahara, Kudo Keiko, Toshio Kawasaki

研究成果: Contribution to journalArticle査読

16 被引用数 (Scopus)

抄録

Two spirostanol glycosides (steroid saponins) R-3 (I) and R-8 (II), which were regarded, respectively, as pure 1-0-α-L-rhamnopyranosyl-(1-2)-β-D-xylopyranoside and 3-0-β-D-glucopyranoside of rhodeasapogenin(25S) (III), were shown by 13C-NMR to be accompanied by the corresponding glycosides of isorhodeasapogenin(25R) (IV) and conva-llamarogenin(Δ25(27)) (V). Qualitative and preparative separation by HPLC of the components of I and II were studied and successfully achieved by a combination of two methods. They consisted equally of not three but four compounds, which were isolated in the pure state. Three of them were identified as the glycosides of III (major), IV and V, while the fourth was considered to have the same sugar moiety as I or II combined with a new aglycone different from III - V in the F-ring structure. The methods were applied also to some commonly known sterod saponins.

本文言語英語
ページ(範囲)348-351
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
31
1
DOI
出版ステータス出版済み - 1983
外部発表はい

All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 創薬

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