Coaxial double-tubular compliant arterial graft prosthesis: Time-dependent morphogenesis and compliance changes after implantation

Hiromichi Sonoda, Keiichi Takamizawa, Yasuhide Nakayama, Hisataka Yasui, Takehisa Matsuda

研究成果: ジャーナルへの寄稿記事

27 引用 (Scopus)

抄録

In order to reduce the compliance mismatch between the native artery and the artificial graft, we have developed a coaxial double-tubular compliant graft, using multiply micropored segmented polyurethane (SPU) thin films, which mimics the relationship between the intraluminal pressure and vessel internal diameter (P-D) of the native artery (termed "J" curve). The graft was coaxially assembled by inserting a high-compliance inner tube with a heparin-immobilized photocured gelatin coating layer into a low-compliance outer tube with a photocured hydrophilic polymer coating layer. Twenty-eight coaxial double-tubular compliant grafts were implanted into the canine common carotid arteries in an end-to-end fashion for up to 12 months. The overall patency rate was 86% (24/28), and neither rupture nor aneurysmal formation was observed. A neoarterial wall was formed via transanastomotic and transmural tissue ingrowth, resulting in neoarterial tissue formation on the luminal surface and into the intertubular space of the double-tubular graft, accompanied by mainly myofibroblasts and inflammatory cells in the early stage and endothelialization and collagen-rich extracellular matrices in the late stage of implantation. Surrounding-tissue adhesion with the outer tube was prevented by the hydrophilic polymer coating. Although the J curve of the implanted prototype model was preserved 1 month after implantation, the impaired J curves were observed because of tissue ingrowth and tissue adhesion between the outer surface of the inner tube and the surrounding tissues 3 and 6 months after implantation. At 12 months after implantation, however, the implanted coaxial double-tubular graft exhibited high compliance due to biodegradation of the SPU films.

元の言語英語
ページ(範囲)170-181
ページ数12
ジャーナルJournal of Biomedical Materials Research - Part A
65
発行部数2
DOI
出版物ステータス出版済み - 5 1 2003

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Grafts
Tissue
Polyurethanes
Coatings
Polymers
Adhesion
Gelatin
Biodegradation
Collagen
Heparin
Compliance
Prostheses and Implants
Thin films

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

これを引用

Coaxial double-tubular compliant arterial graft prosthesis : Time-dependent morphogenesis and compliance changes after implantation. / Sonoda, Hiromichi; Takamizawa, Keiichi; Nakayama, Yasuhide; Yasui, Hisataka; Matsuda, Takehisa.

:: Journal of Biomedical Materials Research - Part A, 巻 65, 番号 2, 01.05.2003, p. 170-181.

研究成果: ジャーナルへの寄稿記事

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