Cocktail of reactive species generated by cold atmospheric plasma: Oral administration induces non-small cell lung cancer cell death

Chang Hyun Song, Pankaj Attri, Sae Kwang Ku, Ihn Han, Annemie Bogaerts, Eun Ha Choi

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with 85% of all lung cancer reported as NSCLC. Moreover, there are no effective treatments in advanced NSCLC. This study shows for the first time that oral administration of plasma-treated water (PTW) can cure advanced NSCLC. The cold plasma in water generates a cocktail of reactive species, and oral administration of this cocktail to mice showed no toxicities even at the highest dose of PTW, after a single dose and repeated doses for 28 d in mice. In vivo studies reveal that PTW showed favorable anticancer effects on chemo-resistant lung cancer, similarly to gefitinib treatment as a reference drug in a chemo-resistant NSCLC model. The anticancer activities of PTW seem to be involved in inhibiting proliferation and angiogenesis and enhancing apoptosis in the cancer cells. Interestingly, the PTW contributes to enhanced immune response and improved cachexia in the model.

本文言語英語
論文番号abdff2
ジャーナルJournal of Physics D: Applied Physics
54
18
DOI
出版ステータス出版済み - 5 6 2021

All Science Journal Classification (ASJC) codes

  • 電子材料、光学材料、および磁性材料
  • 凝縮系物理学
  • 音響学および超音波学
  • 表面、皮膜および薄膜

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