Coding design of positional information for robust morphogenesis

Yoshihiro Morishita, Yoh Iwasa

研究成果: ジャーナルへの寄稿学術誌査読

6 被引用数 (Scopus)

抄録

Robust positioning of cells in a tissue against unavoidable noises is important for achieving normal and reproducible morphogenesis. The position in a tissue is represented by morphogen concentrations, and cells read them to recognize their spatial coordinates. From the engineering viewpoint, these positioning processes can be regarded as an information coding. Organisms are conjectured to adopt good coding designs with high reliability for a given number of available morphogen species and their chemical properties. To answer, quantitatively, the questions of how good coding is adopted, and subsequently when, where, and to what extent each morphogen contributes to positioning, we need a way to evaluate the goodness of coding. In this article, by introducing basic concepts of computer science, we mathematically formulate coding processes in morphogen-dependent positioning, and define some key concepts such as encoding, decoding, and positional information and its precision. We demonstrate the best designs for pairs of encoding and decoding rules, and show how those designs can be biologically implemented by using some examples. We also propose a possible procedure of data analysis to validate the coding optimality formulated here.

本文言語英語
ページ(範囲)2324-2335
ページ数12
ジャーナルBiophysical Journal
101
10
DOI
出版ステータス出版済み - 11月 16 2011

!!!All Science Journal Classification (ASJC) codes

  • 生物理学

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