COENZYME MODELS - 15. A POLYMERIC MODEL SYSTEM FOR THE NADH-DEPENDENT DEHYDROGENASE ENZYMES.

Seiji Shinkai, Kenji Tanake, Toyoko Ide, Osamu Manabe

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

In the reported experiments, copolymers of 4-vinylpyridine (4-VP) and N-(p-vinylbenzyl)-1,4-dihydronicotinamide (VNicH) were synthesized, and a carbonyl substrate (benzil) was reduced to alcohol in an aqueous ethanol solution in the absence and presence of metal ions (Zn**2** plus and Ni**2** plus ) as part of a model study of NADH-dependent enzymes. The reduction rates by VNicH in polymers were four to seven times greater than that of the corresponding monomeric analog (N-benzyl-1,4-dihydronicotinamide). Added metal ions catalyzed the reduction by VNicH-29 (VNicH content, 29 mole%) but inhibited the reduction by VNicH-9 (VNicH content, 9 mole%). It was suggested that metal catalysis occurs only when metal ions are bound closely near the dihydronicotinamide moiety.

元の言語英語
ページ(範囲)2585-2591
ページ数7
ジャーナルJ Polym Sci Polym Chem Ed
17
発行部数8
出版物ステータス出版済み - 1 1 1979
外部発表Yes

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Coenzymes
Metal ions
Enzymes
Catalysis
Alcohols
Ethanol
Copolymers
Polymers
Substrates
Metals
Oxidoreductases
Experiments

All Science Journal Classification (ASJC) codes

  • Engineering(all)

これを引用

COENZYME MODELS - 15. A POLYMERIC MODEL SYSTEM FOR THE NADH-DEPENDENT DEHYDROGENASE ENZYMES. / Shinkai, Seiji; Tanake, Kenji; Ide, Toyoko; Manabe, Osamu.

:: J Polym Sci Polym Chem Ed, 巻 17, 番号 8, 01.01.1979, p. 2585-2591.

研究成果: ジャーナルへの寄稿記事

Shinkai, S, Tanake, K, Ide, T & Manabe, O 1979, 'COENZYME MODELS - 15. A POLYMERIC MODEL SYSTEM FOR THE NADH-DEPENDENT DEHYDROGENASE ENZYMES.', J Polym Sci Polym Chem Ed, 巻. 17, 番号 8, pp. 2585-2591.
Shinkai, Seiji ; Tanake, Kenji ; Ide, Toyoko ; Manabe, Osamu. / COENZYME MODELS - 15. A POLYMERIC MODEL SYSTEM FOR THE NADH-DEPENDENT DEHYDROGENASE ENZYMES. :: J Polym Sci Polym Chem Ed. 1979 ; 巻 17, 番号 8. pp. 2585-2591.
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abstract = "In the reported experiments, copolymers of 4-vinylpyridine (4-VP) and N-(p-vinylbenzyl)-1,4-dihydronicotinamide (VNicH) were synthesized, and a carbonyl substrate (benzil) was reduced to alcohol in an aqueous ethanol solution in the absence and presence of metal ions (Zn**2** plus and Ni**2** plus ) as part of a model study of NADH-dependent enzymes. The reduction rates by VNicH in polymers were four to seven times greater than that of the corresponding monomeric analog (N-benzyl-1,4-dihydronicotinamide). Added metal ions catalyzed the reduction by VNicH-29 (VNicH content, 29 mole{\%}) but inhibited the reduction by VNicH-9 (VNicH content, 9 mole{\%}). It was suggested that metal catalysis occurs only when metal ions are bound closely near the dihydronicotinamide moiety.",
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N2 - In the reported experiments, copolymers of 4-vinylpyridine (4-VP) and N-(p-vinylbenzyl)-1,4-dihydronicotinamide (VNicH) were synthesized, and a carbonyl substrate (benzil) was reduced to alcohol in an aqueous ethanol solution in the absence and presence of metal ions (Zn**2** plus and Ni**2** plus ) as part of a model study of NADH-dependent enzymes. The reduction rates by VNicH in polymers were four to seven times greater than that of the corresponding monomeric analog (N-benzyl-1,4-dihydronicotinamide). Added metal ions catalyzed the reduction by VNicH-29 (VNicH content, 29 mole%) but inhibited the reduction by VNicH-9 (VNicH content, 9 mole%). It was suggested that metal catalysis occurs only when metal ions are bound closely near the dihydronicotinamide moiety.

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