TY - JOUR
T1 - COENZYME MODELS - 19. OXIDATION OF FUROIN BY A FLAVIN IMMOBILIZED IN CATIONIC POLYELECTROLYTES - A FLAVOENZYME MODEL.
AU - Shinkai, Seiji
PY - 1979
Y1 - 1979
N2 - In the reported study, the rate constants for the oxidation of furoin by a flavin (vitamin B//2 analog) immobilized in catonic polymers were evaluated under anaerobic conditions, and the influence of reaction environments was discussed in connection with the enzymatic reactivity. It was found that (1) proton abstraction from furoin which forms the carbanionic intermediate is rate determining in the initial stage of the reaction and is facilitated by the environment of cationic polymers, (2) proton abstraction is efficiently accelerated by added cationic surfactant (CTAB), and (3) N-dodecylbenzohydroxamic acid in aqueous CTAB acts as an excellent proton-abstracting reagent. the polymers with high dodecyl group content served, in all cases, as better oxidizing reagents. As a summary of these conclusions, the importance of hydrophobic environments in flavin-mediated oxidation was emphasized.
AB - In the reported study, the rate constants for the oxidation of furoin by a flavin (vitamin B//2 analog) immobilized in catonic polymers were evaluated under anaerobic conditions, and the influence of reaction environments was discussed in connection with the enzymatic reactivity. It was found that (1) proton abstraction from furoin which forms the carbanionic intermediate is rate determining in the initial stage of the reaction and is facilitated by the environment of cationic polymers, (2) proton abstraction is efficiently accelerated by added cationic surfactant (CTAB), and (3) N-dodecylbenzohydroxamic acid in aqueous CTAB acts as an excellent proton-abstracting reagent. the polymers with high dodecyl group content served, in all cases, as better oxidizing reagents. As a summary of these conclusions, the importance of hydrophobic environments in flavin-mediated oxidation was emphasized.
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U2 - 10.1002/pol.1979.170171210
DO - 10.1002/pol.1979.170171210
M3 - Article
AN - SCOPUS:0018767801
VL - 17
SP - 3905
EP - 3912
JO - Journal of polymer science. Part A-1, Polymer chemistry
JF - Journal of polymer science. Part A-1, Polymer chemistry
SN - 0449-296X
IS - 12
ER -