Coexistent emphysema delays the decrease of vital capacity in idiopathic pulmonary fibrosis

Takanori Akagi, Takemasa Matsumoto, Taishi Harada, Makoto Tanaka, Takashige Kuraki, Masaki Fujita, Kentaro Watanabe

研究成果: ジャーナルへの寄稿学術誌査読

101 被引用数 (Scopus)

抄録

Although previous authors have reported single data point, yearly changes in respiratory function have not been examined in combined pulmonary fibrosis and emphysema (CPFE). To quantify the annual changes in respiratory function of patients with CPFE and to examine the difference in survival between CPFE patients and patients with idiopathic pulmonary fibrosis without emphysema (IPF alone), 26 patients with CPFE and 33 IPF alone patients, whose respiratory function had been monitored for at least a year, were selected. The baseline of vital capacity percent predicted (VC% pred) in CPFE patients was greater than that in IPF-alone patients (86.6 ± 24.0% vs. 72.8 ± 19.4%, p = 0.018). The annual decrease in VC% pred was significantly less in CPFE patients than in IPF-alone patients (-1.2 ± 4.8% vs. -8.0 ± 7.4%, p < 0.001). Baseline ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC%) in CPFE patients was lower than that in IPF-alone patients (76.6 ± 8.5% vs. 85.2 ± 6.7%, p < 0.001). In the CPFE group, FEV1/FVC% tended to decrease with time (-0.5 ± 2.2% per year), but, in contrast, it increased in IPF-alone patients (+1.1 ± 3.4% per year) (p = 0.036). Baseline of diffusing capacity percent predicted (DLco% pred) was significantly lower in CPFE patients than in IPF-alone patients (45.3 ± 15.0% vs. 60.7 ± 19.8%, p = 0.003). The annual decrease in DLco% pred was lower in CPFE patients than in IPF-alone patients (-3.7 ± 7.9% vs. -10.7 ± 8.8%, p = 0.042). There was no significant difference in the survival duration between 26 CPFE and 33 IPF-alone patients according to Kaplan-Meier analysis. Ventilatory and gas-exchange deterioration during the course of IPF became mild when emphysema was coexistent.

本文言語英語
ページ(範囲)1209-1215
ページ数7
ジャーナルRespiratory Medicine
103
8
DOI
出版ステータス出版済み - 8月 2009
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 呼吸器内科

フィンガープリント

「Coexistent emphysema delays the decrease of vital capacity in idiopathic pulmonary fibrosis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル