Colloidal nanoparticles from Poly(N-isopropylacrylamide)-graft-DNA for single nucleotide discrimination based on salt-induced aggregation: Extension to long target DNA

Zhonglan Tang, Tohru Takarada, Yoshikuni Sato, Mizuo Maeda

研究成果: Contribution to journalArticle査読

16 被引用数 (Scopus)

抄録

The DNA-linked colloidal nanoparticle was prepared through the phase transition of the amphiphilic copolymer consisting of DNA as the hydrophilic part and thermo-responsive poly(N-isopropylacrylamide) as the hydrophobic part. We have succeeded in detecting the single nucleotide difference of 39-mer target DNA by using a salt-induced aggregation of the particles.

本文言語英語
ページ(範囲)1602-1603
ページ数2
ジャーナルChemistry Letters
33
12
DOI
出版ステータス出版済み - 12 5 2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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