Colorectal polypectomy and risk of colorectal cancer by subsite: The Fukuoka colorectal cancer study

Daigo Yoshida, Suminori Kono, Malcolm A. Moore, Kengo Toyomura, Jun Nagano, Tetsuya Mizoue, Ryuichi Mibu, Masao Tanaka, Yoshihiro Kakeji, Yoshihiko Maehara, Takeshi Okamura, Koji Ikejiri, Kitaroh Futami, Yohichi Yasunami, Takafumi Maekawa, Kenji Takenaka, Hitoshi Ichimiya, Nobutoshi Imaizumi

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Background: Colorectal adenomas are well-established precursor lesions for colorectal cancer and removal of polyps is deemed to reduce the risk of colorectal cancer. However, benefit of colorectal polypectomy in routine practice is still uncertain. We therefore investigated subsite-specific risks of colorectal cancer in relation to history of colorectal polypectomy in a case-control study. Methods: Both case patients and control subjects were residents aged 20-74 years in Fukuoka City and three adjacent areas. The case group comprised 840 patients undergoing surgery for a first diagnosis of colorectal cancer, while the control subjects were 833 residents who were selected in the community by two-stage random sampling. Past history of selected diseases, surgery and lifestyle factors were ascertained by in-person interview. Statistical adjustment was made for sex, 5-year age class, residence, smoking, alcohol drinking, physical activity, body mass index and parental history of colorectal cancer. Results: Overall, 74 case patients (9%) and 85 control subjects (10%) reported a prior history of colorectal polyps, and 50 cases (6%) and 64 controls (8%) had a history of colorectal polypectomy. The adjusted odds ratio associated with colorectal polypectomy was 0.71 (95% confidence interval [CI] 0.48-1.06) for the overall risk of colorectal cancer. The corresponding values for cancer of the proximal colon, distal colon, and rectum were 1.68 (95% CI 0.98-2.88), 0.71 (95% CI 0.41-1.26) and 0.24 (95% CI 0.11-0.52), respectively. Conclusions: The findings indicate that colorectal polypectomy in current practice confers a decreased risk of rectal cancer and possibly of distal colon cancer.

元の言語英語
ページ(範囲)597-602
ページ数6
ジャーナルJapanese journal of clinical oncology
37
発行部数8
DOI
出版物ステータス出版済み - 8 2007

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

フィンガープリント Colorectal polypectomy and risk of colorectal cancer by subsite: The Fukuoka colorectal cancer study' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Yoshida, D., Kono, S., Moore, M. A., Toyomura, K., Nagano, J., Mizoue, T., Mibu, R., Tanaka, M., Kakeji, Y., Maehara, Y., Okamura, T., Ikejiri, K., Futami, K., Yasunami, Y., Maekawa, T., Takenaka, K., Ichimiya, H., & Imaizumi, N. (2007). Colorectal polypectomy and risk of colorectal cancer by subsite: The Fukuoka colorectal cancer study. Japanese journal of clinical oncology, 37(8), 597-602. https://doi.org/10.1093/jjco/hym065