Colorimetric/fluorogenic detection of thiols by N-fused porphyrin in water

Yoshiya Ikawa, Satoshi Touden, Sho Katsumata, Hiroyuki Furuta

    研究成果: Contribution to journalArticle査読

    9 被引用数 (Scopus)

    抄録

    A water-soluble derivative of N-fused porphyrin (NFP) possessing four cationic side-arms (pPyNFP) serves as a unique class of colorimetric/fluorogenic reporters that selectively react with biothiols in aquaous media to afford N-confused porphyrin (NCP) derivatives, while other nucleophilic amino acids were inert under a wide range of pH conditions. Owing to the large difference of the optical properties between NCP and NFP, the transformation enabled selective detection of biothiols in colorimetric/fluorogenic manner, especially in the near-infrared region. To the best our knowledge, this is the first example of porphyrin-based thiol detection systems that use the direct attack of thiol group on the optical reporter.

    本文言語英語
    ページ(範囲)6501-6505
    ページ数5
    ジャーナルBioorganic and Medicinal Chemistry
    21
    21
    DOI
    出版ステータス出版済み - 11 1 2013

    All Science Journal Classification (ASJC) codes

    • 生化学
    • 分子医療
    • 分子生物学
    • 薬科学
    • 創薬
    • 臨床生化学
    • 有機化学

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