Combination chemotherapy with methotrexate and 5-fluorouracil and surgery for advanced gastric cancer with liver and lymph node metastases: A case report

D. Korenaga, F. Takesue, Y. Toh, S. Maekawa, T. Ikeda, K. Sugimachi

研究成果: ジャーナルへの寄稿学術誌査読

抄録

We report on a case of advanced gastric cancer with multiple liver metastasis and lymph node metastases in a 65-year-old Japanese man. He was treated with sequential intravenous administration of moderate-dose methotrexate (MTX) and 5-fluorouracil (5-FU) preoperatively. After eleven cycles of the combination chemotherapy, the findings of liver and lymph node metastases diminished dramatically and the tumor could be resected for a potential cure, using a total gastrectomy and combined hepatectomy. The resected specimen revealed a slightly elevated lesion and a somewhat shallow ulceration due to chemotherapy. Histologically, there was an infiltration of poorly differentiated adenocarcinomas with medullary structure in the muscularis mucosae with fibrous change. The liver was metastasized, but there was no evidence of lymph node metastasis. We believe that combination chemotherapy of MTX and 5-FU can be effective against gastric cancer.

本文言語英語
ページ(範囲)505-507
ページ数3
ジャーナルOncology reports
2
4
DOI
出版ステータス出版済み - 1995
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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