Combination of hepatocellular markers is useful for prognostication in gastric hepatoid adenocarcinoma

Mikako Osada, Shinichi Aishima, Minako Hirahashi, Nobuyoshi Takizawa, Shunsuke Takahashi, Kazuhiko Nakamura, Masao Tanaka, Yoshihiko Maehara, Ryoichi Takayanagi, Yoshinao Oda

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

抄録

Hepatoid or α-fetoprotein (AFP)-producing adenocarcinomas of stomach growing in a solid pattern are highly aggressive tumors. It is difficult to detect hepatoid differentiation solely based on findings from hematoxylin and eosin stainings, especially in small biopsy specimens. Gastric adenocarcinomas with hepatoid differentiation should be distinguished from solid-type gastric adenocarcinoma because of their different biological behavior. We immunohistochemically analyzed hepatocellular markers (AFP, glypican 3, and Hepatocyte paraffin 1 [HepPar-1]) and possible markers of gastric hepatoid adenocarcinoma (Sal-like protein 4 [SALL4] and palate, lung, and nasal epithelium carcinoma-associated protein [PLUNC]) to detect hepatoid differentiation in 45 gastric hepatoid adenocarcinomas and 47 nonhepatoid solid-type poorly differentiated adenocarcinomas. There were a higher incidence of vascular invasion (P =.0055) and distant metastasis (P =.0458) in hepatoid adenocarcinoma than in nonhepatoid adenocarcinoma. AFP, SALL4, HepPar-1, and glypican 3 were significantly higher in hepatoid adenocarcinoma than in nonhepatoid adenocarcinoma. All 5 markers were positive in both the hepatoid/solid and the tubular component. In hepatoid adenocarcinoma, the frequency of distant metastasis was significantly higher in SALL4-negative cases than in SALL4-positive cases (P =.0381). HepPar-1 was associated with liver metastasis (P =.0452). PLUNC was correlated with lymph node metastasis (P =.0375). There was a significant difference in the survival rate between HepPar-1-positive and HepPar-1-negative groups (P =.0437). The coexpression of PLUNC and SALL4 and the other coexpression of HepPar-1 and PLUNC were associated with poorer prognosis (P =.0181 and P =.0443, respectively). AFP, SALL4, HepPar-1, and glypican 3 are useful for the detection of hepatoid differentiation. A combination of PLUNC, HepPar-1, and SALL4 could be a reliable prognostic indicator in hepatoid adenocarcinoma of the stomach.

元の言語英語
ページ(範囲)1243-1250
ページ数8
ジャーナルHuman Pathology
45
発行部数6
DOI
出版物ステータス出版済み - 1 1 2014

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Stomach
Adenocarcinoma
Paraffin
Hepatocytes
Nasal Mucosa
Palate
Proteins
Glypicans
Carcinoma
Lung
Neoplasm Metastasis
Fetal Proteins
Hematoxylin
Eosine Yellowish-(YS)
Blood Vessels
Lymph Nodes
Staining and Labeling
Biopsy
Liver
Incidence

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

これを引用

Combination of hepatocellular markers is useful for prognostication in gastric hepatoid adenocarcinoma. / Osada, Mikako; Aishima, Shinichi; Hirahashi, Minako; Takizawa, Nobuyoshi; Takahashi, Shunsuke; Nakamura, Kazuhiko; Tanaka, Masao; Maehara, Yoshihiko; Takayanagi, Ryoichi; Oda, Yoshinao.

:: Human Pathology, 巻 45, 番号 6, 01.01.2014, p. 1243-1250.

研究成果: ジャーナルへの寄稿記事

Osada, M, Aishima, S, Hirahashi, M, Takizawa, N, Takahashi, S, Nakamura, K, Tanaka, M, Maehara, Y, Takayanagi, R & Oda, Y 2014, 'Combination of hepatocellular markers is useful for prognostication in gastric hepatoid adenocarcinoma', Human Pathology, 巻. 45, 番号 6, pp. 1243-1250. https://doi.org/10.1016/j.humpath.2014.02.003
Osada M, Aishima S, Hirahashi M, Takizawa N, Takahashi S, Nakamura K その他. Combination of hepatocellular markers is useful for prognostication in gastric hepatoid adenocarcinoma. Human Pathology. 2014 1 1;45(6):1243-1250. https://doi.org/10.1016/j.humpath.2014.02.003
Osada, Mikako ; Aishima, Shinichi ; Hirahashi, Minako ; Takizawa, Nobuyoshi ; Takahashi, Shunsuke ; Nakamura, Kazuhiko ; Tanaka, Masao ; Maehara, Yoshihiko ; Takayanagi, Ryoichi ; Oda, Yoshinao. / Combination of hepatocellular markers is useful for prognostication in gastric hepatoid adenocarcinoma. :: Human Pathology. 2014 ; 巻 45, 番号 6. pp. 1243-1250.
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abstract = "Hepatoid or α-fetoprotein (AFP)-producing adenocarcinomas of stomach growing in a solid pattern are highly aggressive tumors. It is difficult to detect hepatoid differentiation solely based on findings from hematoxylin and eosin stainings, especially in small biopsy specimens. Gastric adenocarcinomas with hepatoid differentiation should be distinguished from solid-type gastric adenocarcinoma because of their different biological behavior. We immunohistochemically analyzed hepatocellular markers (AFP, glypican 3, and Hepatocyte paraffin 1 [HepPar-1]) and possible markers of gastric hepatoid adenocarcinoma (Sal-like protein 4 [SALL4] and palate, lung, and nasal epithelium carcinoma-associated protein [PLUNC]) to detect hepatoid differentiation in 45 gastric hepatoid adenocarcinomas and 47 nonhepatoid solid-type poorly differentiated adenocarcinomas. There were a higher incidence of vascular invasion (P =.0055) and distant metastasis (P =.0458) in hepatoid adenocarcinoma than in nonhepatoid adenocarcinoma. AFP, SALL4, HepPar-1, and glypican 3 were significantly higher in hepatoid adenocarcinoma than in nonhepatoid adenocarcinoma. All 5 markers were positive in both the hepatoid/solid and the tubular component. In hepatoid adenocarcinoma, the frequency of distant metastasis was significantly higher in SALL4-negative cases than in SALL4-positive cases (P =.0381). HepPar-1 was associated with liver metastasis (P =.0452). PLUNC was correlated with lymph node metastasis (P =.0375). There was a significant difference in the survival rate between HepPar-1-positive and HepPar-1-negative groups (P =.0437). The coexpression of PLUNC and SALL4 and the other coexpression of HepPar-1 and PLUNC were associated with poorer prognosis (P =.0181 and P =.0443, respectively). AFP, SALL4, HepPar-1, and glypican 3 are useful for the detection of hepatoid differentiation. A combination of PLUNC, HepPar-1, and SALL4 could be a reliable prognostic indicator in hepatoid adenocarcinoma of the stomach.",
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T1 - Combination of hepatocellular markers is useful for prognostication in gastric hepatoid adenocarcinoma

AU - Osada, Mikako

AU - Aishima, Shinichi

AU - Hirahashi, Minako

AU - Takizawa, Nobuyoshi

AU - Takahashi, Shunsuke

AU - Nakamura, Kazuhiko

AU - Tanaka, Masao

AU - Maehara, Yoshihiko

AU - Takayanagi, Ryoichi

AU - Oda, Yoshinao

PY - 2014/1/1

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N2 - Hepatoid or α-fetoprotein (AFP)-producing adenocarcinomas of stomach growing in a solid pattern are highly aggressive tumors. It is difficult to detect hepatoid differentiation solely based on findings from hematoxylin and eosin stainings, especially in small biopsy specimens. Gastric adenocarcinomas with hepatoid differentiation should be distinguished from solid-type gastric adenocarcinoma because of their different biological behavior. We immunohistochemically analyzed hepatocellular markers (AFP, glypican 3, and Hepatocyte paraffin 1 [HepPar-1]) and possible markers of gastric hepatoid adenocarcinoma (Sal-like protein 4 [SALL4] and palate, lung, and nasal epithelium carcinoma-associated protein [PLUNC]) to detect hepatoid differentiation in 45 gastric hepatoid adenocarcinomas and 47 nonhepatoid solid-type poorly differentiated adenocarcinomas. There were a higher incidence of vascular invasion (P =.0055) and distant metastasis (P =.0458) in hepatoid adenocarcinoma than in nonhepatoid adenocarcinoma. AFP, SALL4, HepPar-1, and glypican 3 were significantly higher in hepatoid adenocarcinoma than in nonhepatoid adenocarcinoma. All 5 markers were positive in both the hepatoid/solid and the tubular component. In hepatoid adenocarcinoma, the frequency of distant metastasis was significantly higher in SALL4-negative cases than in SALL4-positive cases (P =.0381). HepPar-1 was associated with liver metastasis (P =.0452). PLUNC was correlated with lymph node metastasis (P =.0375). There was a significant difference in the survival rate between HepPar-1-positive and HepPar-1-negative groups (P =.0437). The coexpression of PLUNC and SALL4 and the other coexpression of HepPar-1 and PLUNC were associated with poorer prognosis (P =.0181 and P =.0443, respectively). AFP, SALL4, HepPar-1, and glypican 3 are useful for the detection of hepatoid differentiation. A combination of PLUNC, HepPar-1, and SALL4 could be a reliable prognostic indicator in hepatoid adenocarcinoma of the stomach.

AB - Hepatoid or α-fetoprotein (AFP)-producing adenocarcinomas of stomach growing in a solid pattern are highly aggressive tumors. It is difficult to detect hepatoid differentiation solely based on findings from hematoxylin and eosin stainings, especially in small biopsy specimens. Gastric adenocarcinomas with hepatoid differentiation should be distinguished from solid-type gastric adenocarcinoma because of their different biological behavior. We immunohistochemically analyzed hepatocellular markers (AFP, glypican 3, and Hepatocyte paraffin 1 [HepPar-1]) and possible markers of gastric hepatoid adenocarcinoma (Sal-like protein 4 [SALL4] and palate, lung, and nasal epithelium carcinoma-associated protein [PLUNC]) to detect hepatoid differentiation in 45 gastric hepatoid adenocarcinomas and 47 nonhepatoid solid-type poorly differentiated adenocarcinomas. There were a higher incidence of vascular invasion (P =.0055) and distant metastasis (P =.0458) in hepatoid adenocarcinoma than in nonhepatoid adenocarcinoma. AFP, SALL4, HepPar-1, and glypican 3 were significantly higher in hepatoid adenocarcinoma than in nonhepatoid adenocarcinoma. All 5 markers were positive in both the hepatoid/solid and the tubular component. In hepatoid adenocarcinoma, the frequency of distant metastasis was significantly higher in SALL4-negative cases than in SALL4-positive cases (P =.0381). HepPar-1 was associated with liver metastasis (P =.0452). PLUNC was correlated with lymph node metastasis (P =.0375). There was a significant difference in the survival rate between HepPar-1-positive and HepPar-1-negative groups (P =.0437). The coexpression of PLUNC and SALL4 and the other coexpression of HepPar-1 and PLUNC were associated with poorer prognosis (P =.0181 and P =.0443, respectively). AFP, SALL4, HepPar-1, and glypican 3 are useful for the detection of hepatoid differentiation. A combination of PLUNC, HepPar-1, and SALL4 could be a reliable prognostic indicator in hepatoid adenocarcinoma of the stomach.

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