Combination therapy of resection and intraoperative radiation for patients with carcinomas of extrahepatic bile duct and ampulla of Vater: Prognostic advantage over resection alone?

Kenji Nakano, Kazuo Chijiiwa, Takayuki Toyonaga, Junji Ueda, Yuji Takamatsu, Masahiko Kimura, Katsumasa Nakamura, Koji Yamaguchi, Masao Tanaka

    研究成果: Contribution to journalArticle査読

    7 被引用数 (Scopus)

    抄録

    Background/Aims: To investigate the therapeutic efficacy of intraoperative radiation for carcinomas of the bile duct and ampulla of Vater. Methodology: Postoperative morbidity, mortality and survival of patients undergoing surgical resection of ampullary cancer (n=19) and bile duct cancer (n=28) were retrospectively compared between two groups with and without intraoperative radiation. Results: Background items (age, gender, preoperative laboratory data, operative time and bleeding volume, tumor stage) did not differ significantly between the two groups. The predominant postoperative complication was leakage of pancreatic juice, which occurred in similar rates in both groups. No significant differences were noted in the 3-year survival rates between the resection plus intraoperative radiation group and resection alone group (60.0% (n=5) vs. 50.1% (n=13) for ampullary cancer; 0% (n=4) vs. 27.1% (n=24) for bile duct cancer, respectively). The main causes of recurrence were distant metastasis for ampullary cancer and microscopic residue of carcinoma for bile duct cancer. Conclusions: The combination of intraoperative radiation and resection may add no significant benefit to patients with ampullary and bile duct cancer when compared with resection alone.

    本文言語英語
    ページ(範囲)928-933
    ページ数6
    ジャーナルHepato-gastroenterology
    50
    52
    出版ステータス出版済み - 7 2003

    All Science Journal Classification (ASJC) codes

    • 肝臓学
    • 消化器病学

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