Combined antibacterial effects of between meropenem and vancomycin, teicoplanin, linezolid, or arbekacin in methicillin-resistant Staphylococcus aureus

Noriko Tsuchimochi, Yujiro Uchida, Yoji Nagasaki, Yoshihiro Eriguchi, Yoriko Maehara, Masako Kadowaki, Nobuyuki Shimono

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

In vitro interaction between meropenem(MEPM) and vancomycin(VCM), teicoplanin(TEIC), linezolid (LZD) , or arbekacin(ABK) was studied using the checkerboard technique in 207 clinical isolates of methicillin-resistant Staphylococcus aureus(MRSA) (MIC of MEPM ≧32). Of 207 strains, synergistic or additive action was observed in all strains by combination of MEPM and VCM or TEIC. A combination of MEPM and LZD or ABK showed synergistic or additive 196 strains (94.7%) and 159 strains (76.8%). Antagonism was not observed in any combination of MEPM and VCM, TEIC, or LZD, but 22 strains (10.6%) exhibited antagonism in combination with MEPM and ABK. It is thus important to know both the susceptibility of anti-MRSA agents alone and the combined effects of agents.

元の言語英語
ページ(範囲)363-367
ページ数5
ジャーナルJapanese Journal of Chemotherapy
55
発行部数5
出版物ステータス出版済み - 9 1 2007

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Linezolid
meropenem
Teicoplanin
Vancomycin
Methicillin-Resistant Staphylococcus aureus
habekacin

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

これを引用

Combined antibacterial effects of between meropenem and vancomycin, teicoplanin, linezolid, or arbekacin in methicillin-resistant Staphylococcus aureus. / Tsuchimochi, Noriko; Uchida, Yujiro; Nagasaki, Yoji; Eriguchi, Yoshihiro; Maehara, Yoriko; Kadowaki, Masako; Shimono, Nobuyuki.

:: Japanese Journal of Chemotherapy, 巻 55, 番号 5, 01.09.2007, p. 363-367.

研究成果: ジャーナルへの寄稿記事

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abstract = "In vitro interaction between meropenem(MEPM) and vancomycin(VCM), teicoplanin(TEIC), linezolid (LZD) , or arbekacin(ABK) was studied using the checkerboard technique in 207 clinical isolates of methicillin-resistant Staphylococcus aureus(MRSA) (MIC of MEPM ≧32). Of 207 strains, synergistic or additive action was observed in all strains by combination of MEPM and VCM or TEIC. A combination of MEPM and LZD or ABK showed synergistic or additive 196 strains (94.7{\%}) and 159 strains (76.8{\%}). Antagonism was not observed in any combination of MEPM and VCM, TEIC, or LZD, but 22 strains (10.6{\%}) exhibited antagonism in combination with MEPM and ABK. It is thus important to know both the susceptibility of anti-MRSA agents alone and the combined effects of agents.",
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AU - Tsuchimochi, Noriko

AU - Uchida, Yujiro

AU - Nagasaki, Yoji

AU - Eriguchi, Yoshihiro

AU - Maehara, Yoriko

AU - Kadowaki, Masako

AU - Shimono, Nobuyuki

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