Combining microarrays and biological knowledge for estimating gene networks via Bayesian networks

S. Imoto, T. Higuchi, T. Goto, K. Tashiro, S. Kuhara, S. Miyano

研究成果: 著書/レポートタイプへの貢献会議での発言

83 引用 (Scopus)

抜粋

We propose a statistical method for estimating a gene network based on Bayesian networks from microarray gene expression data together with biological knowledge including protein-protein interactions, protein-DNA interactions, binding site information, existing literature and so on. Unfortunately, microarray data do not contain enough information for constructing gene networks accurately in many cases. Our method adds biological knowledge to the estimation method of gene networks under a Bayesian statistical framework, and also controls the trade-off between microarray information and biological knowledge automatically. We conduct Monte Carlo simulations to show the effectiveness of the proposed method. We analyze Saccharomyces cerevisiae gene expression data as an application.

元の言語英語
ホスト出版物のタイトルProceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003
出版者Institute of Electrical and Electronics Engineers Inc.
ページ104-113
ページ数10
ISBN(電子版)0769520006, 9780769520001
DOI
出版物ステータス出版済み - 1 1 2003
イベント2nd International IEEE Computer Society Computational Systems Bioinformatics Conference, CSB 2003 - Stanford, 米国
継続期間: 8 11 20038 14 2003

出版物シリーズ

名前Proceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003

その他

その他2nd International IEEE Computer Society Computational Systems Bioinformatics Conference, CSB 2003
米国
Stanford
期間8/11/038/14/03

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering
  • Computer Science Applications

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  • これを引用

    Imoto, S., Higuchi, T., Goto, T., Tashiro, K., Kuhara, S., & Miyano, S. (2003). Combining microarrays and biological knowledge for estimating gene networks via Bayesian networks. : Proceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003 (pp. 104-113). [1227309] (Proceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CSB.2003.1227309