Comparative effects of pentazocine on the auditory evoked potential index (AEP) and the bispectral index (BIS) under nitrous oxide sevoflurane anesthesia

Kazuyuki Onuki, Hiroshi Oyake, Yuichirou Yamanishi, Shigenori Uchida, Toshikatsu Imamura, Masanori Tsukamoto, Shumei Yoshikawa, Tooru Tajima, Jun Shimada, Akihiko Hasegawa, Hiroshi Nagasaka

研究成果: ジャーナルへの寄稿記事

抄録

Background : The auditory evoked potential index (AEP) and the bispectral index (BIS) can be used to assess the depth of general anesthesia Pentazocine is reported to increase the BIS value in anesthetized patients and may confound use of the index as a guide to administering hypnosis. In this study, we compared the effects of pentazocine on AEP values and BIS values in the absence of surgical stimulation under nitrous oxide sevoflurane anesthesia. Methods : The study was approved by the ethics committee of our institution, and written informed consent was obtained from all patients. Patients with known psychiatric, cardiovascular, neurological or endocrine disorders were excluded from the study. Twenty adult patients (ASA I) scheduled for elective oral surgery were studied, and assigned to one of two groups : AEP group (n = 10) and BIS group (n = 10). Anesthesia was induced with thiopental sodium and vecuronium bromide and maintained with a mixture of nitrous oxide (4 l·min-1), oxygen (2 l·min-1 and sevoflurane (1%). Mean arterial blood pressure (MAP), heart rate (HR), and either AEP values or BIS values were recorded every 2.5 min after intubation up to 30 min before surgery. Pentazocine (0.6 mg·kg-1) was administered intravenously (IV) 15 min after intubation. Data were presented as mean±SD, and results were analyzed by using repeated-measures analysis of variance. Post hoc comparisons were done using Tukey's test. For comparison between AEP and BIS groups, Student's test or χ2 test was used. P<0.05 was considered significant. Results : MAP and HR showed no significant differences between values before and after IV pentazocine, and between AEP and BIS groups. BIS values increased significantly (p<0.01) at 5 min after pentazocine IV, whereas AEP values showed no significant changes in response to pentazocine IV. Conclusions : IV pentazocine revealed different aspects of neural processing between AEP and BIS during nitrous oxide sevoflurane anesthesia The significant increase in BIS values, but not AEP values, elicited by pentazocine is paradoxical in that it is associated with a deepening level of hypnosis.

元の言語英語
ページ(範囲)628-632
ページ数5
ジャーナルJournal of Japanese Dental Society of Anesthesiology
39
発行部数5
出版物ステータス出版済み - 11 16 2011
外部発表Yes

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Pentazocine
Auditory Evoked Potentials
Nitrous Oxide
Anesthesia
Arterial Pressure
Hypnosis
Intubation
Heart Rate
sevoflurane
Vecuronium Bromide
Ethics Committees
Thiopental
Oral Surgery
Informed Consent
General Anesthesia
Psychiatry
Analysis of Variance
Students
Oxygen

All Science Journal Classification (ASJC) codes

  • Dentistry(all)
  • Anesthesiology and Pain Medicine

これを引用

Comparative effects of pentazocine on the auditory evoked potential index (AEP) and the bispectral index (BIS) under nitrous oxide sevoflurane anesthesia. / Onuki, Kazuyuki; Oyake, Hiroshi; Yamanishi, Yuichirou; Uchida, Shigenori; Imamura, Toshikatsu; Tsukamoto, Masanori; Yoshikawa, Shumei; Tajima, Tooru; Shimada, Jun; Hasegawa, Akihiko; Nagasaka, Hiroshi.

:: Journal of Japanese Dental Society of Anesthesiology, 巻 39, 番号 5, 16.11.2011, p. 628-632.

研究成果: ジャーナルへの寄稿記事

Onuki, K, Oyake, H, Yamanishi, Y, Uchida, S, Imamura, T, Tsukamoto, M, Yoshikawa, S, Tajima, T, Shimada, J, Hasegawa, A & Nagasaka, H 2011, 'Comparative effects of pentazocine on the auditory evoked potential index (AEP) and the bispectral index (BIS) under nitrous oxide sevoflurane anesthesia', Journal of Japanese Dental Society of Anesthesiology, 巻. 39, 番号 5, pp. 628-632.
Onuki, Kazuyuki ; Oyake, Hiroshi ; Yamanishi, Yuichirou ; Uchida, Shigenori ; Imamura, Toshikatsu ; Tsukamoto, Masanori ; Yoshikawa, Shumei ; Tajima, Tooru ; Shimada, Jun ; Hasegawa, Akihiko ; Nagasaka, Hiroshi. / Comparative effects of pentazocine on the auditory evoked potential index (AEP) and the bispectral index (BIS) under nitrous oxide sevoflurane anesthesia. :: Journal of Japanese Dental Society of Anesthesiology. 2011 ; 巻 39, 番号 5. pp. 628-632.
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abstract = "Background : The auditory evoked potential index (AEP) and the bispectral index (BIS) can be used to assess the depth of general anesthesia Pentazocine is reported to increase the BIS value in anesthetized patients and may confound use of the index as a guide to administering hypnosis. In this study, we compared the effects of pentazocine on AEP values and BIS values in the absence of surgical stimulation under nitrous oxide sevoflurane anesthesia. Methods : The study was approved by the ethics committee of our institution, and written informed consent was obtained from all patients. Patients with known psychiatric, cardiovascular, neurological or endocrine disorders were excluded from the study. Twenty adult patients (ASA I) scheduled for elective oral surgery were studied, and assigned to one of two groups : AEP group (n = 10) and BIS group (n = 10). Anesthesia was induced with thiopental sodium and vecuronium bromide and maintained with a mixture of nitrous oxide (4 l·min-1), oxygen (2 l·min-1 and sevoflurane (1{\%}). Mean arterial blood pressure (MAP), heart rate (HR), and either AEP values or BIS values were recorded every 2.5 min after intubation up to 30 min before surgery. Pentazocine (0.6 mg·kg-1) was administered intravenously (IV) 15 min after intubation. Data were presented as mean±SD, and results were analyzed by using repeated-measures analysis of variance. Post hoc comparisons were done using Tukey's test. For comparison between AEP and BIS groups, Student's test or χ2 test was used. P<0.05 was considered significant. Results : MAP and HR showed no significant differences between values before and after IV pentazocine, and between AEP and BIS groups. BIS values increased significantly (p<0.01) at 5 min after pentazocine IV, whereas AEP values showed no significant changes in response to pentazocine IV. Conclusions : IV pentazocine revealed different aspects of neural processing between AEP and BIS during nitrous oxide sevoflurane anesthesia The significant increase in BIS values, but not AEP values, elicited by pentazocine is paradoxical in that it is associated with a deepening level of hypnosis.",
author = "Kazuyuki Onuki and Hiroshi Oyake and Yuichirou Yamanishi and Shigenori Uchida and Toshikatsu Imamura and Masanori Tsukamoto and Shumei Yoshikawa and Tooru Tajima and Jun Shimada and Akihiko Hasegawa and Hiroshi Nagasaka",
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T1 - Comparative effects of pentazocine on the auditory evoked potential index (AEP) and the bispectral index (BIS) under nitrous oxide sevoflurane anesthesia

AU - Onuki, Kazuyuki

AU - Oyake, Hiroshi

AU - Yamanishi, Yuichirou

AU - Uchida, Shigenori

AU - Imamura, Toshikatsu

AU - Tsukamoto, Masanori

AU - Yoshikawa, Shumei

AU - Tajima, Tooru

AU - Shimada, Jun

AU - Hasegawa, Akihiko

AU - Nagasaka, Hiroshi

PY - 2011/11/16

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N2 - Background : The auditory evoked potential index (AEP) and the bispectral index (BIS) can be used to assess the depth of general anesthesia Pentazocine is reported to increase the BIS value in anesthetized patients and may confound use of the index as a guide to administering hypnosis. In this study, we compared the effects of pentazocine on AEP values and BIS values in the absence of surgical stimulation under nitrous oxide sevoflurane anesthesia. Methods : The study was approved by the ethics committee of our institution, and written informed consent was obtained from all patients. Patients with known psychiatric, cardiovascular, neurological or endocrine disorders were excluded from the study. Twenty adult patients (ASA I) scheduled for elective oral surgery were studied, and assigned to one of two groups : AEP group (n = 10) and BIS group (n = 10). Anesthesia was induced with thiopental sodium and vecuronium bromide and maintained with a mixture of nitrous oxide (4 l·min-1), oxygen (2 l·min-1 and sevoflurane (1%). Mean arterial blood pressure (MAP), heart rate (HR), and either AEP values or BIS values were recorded every 2.5 min after intubation up to 30 min before surgery. Pentazocine (0.6 mg·kg-1) was administered intravenously (IV) 15 min after intubation. Data were presented as mean±SD, and results were analyzed by using repeated-measures analysis of variance. Post hoc comparisons were done using Tukey's test. For comparison between AEP and BIS groups, Student's test or χ2 test was used. P<0.05 was considered significant. Results : MAP and HR showed no significant differences between values before and after IV pentazocine, and between AEP and BIS groups. BIS values increased significantly (p<0.01) at 5 min after pentazocine IV, whereas AEP values showed no significant changes in response to pentazocine IV. Conclusions : IV pentazocine revealed different aspects of neural processing between AEP and BIS during nitrous oxide sevoflurane anesthesia The significant increase in BIS values, but not AEP values, elicited by pentazocine is paradoxical in that it is associated with a deepening level of hypnosis.

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