Comparative genomics approach toward critical determinants for the imprinting of an evolutionarily conserved gene Impact

Kohji Okamura, Yoshiyuki Sakaki, Takashi Ito

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

抄録

The Impact is an evolutionarily conserved gene subjected to genomic imprinting in mouse but not in human. A characteristic tandem repeat similar to those found in many other imprinted genes and an elevated expression level, both observed only for the mouse gene, are implicated in the evolution of imprinting, to which the repeat might have contributed via enhancement of the expression. To pursue the possibility further, we examined the correlation among the repeat, expression level, and imprinting of Impact in various mammals ranging from rodents, lagomorphs, carnivores, artiodactyls to primates. Intriguingly, rabbit Impact is abundantly expressed and imprinted like those of rodents, but is missing the repeat from its first intron like those of other mammals that express both alleles weakly. It thus seems that lineage-specific enhancement of gene expression rather than the tandem repeat per se played a critical role in the evolution of imprinting of Impact.

元の言語英語
ページ(範囲)824-830
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
329
発行部数3
DOI
出版物ステータス出版済み - 4 15 2005

Fingerprint

Tandem Repeat Sequences
Genomics
Mammals
Rodentia
Genes
Lagomorpha
Genomic Imprinting
Gene Expression
Introns
Primates
Alleles
Rabbits
Gene expression

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

これを引用

Comparative genomics approach toward critical determinants for the imprinting of an evolutionarily conserved gene Impact. / Okamura, Kohji; Sakaki, Yoshiyuki; Ito, Takashi.

:: Biochemical and Biophysical Research Communications, 巻 329, 番号 3, 15.04.2005, p. 824-830.

研究成果: ジャーナルへの寄稿記事

@article{00a2f0f476de4caea067861c2ee0565c,
title = "Comparative genomics approach toward critical determinants for the imprinting of an evolutionarily conserved gene Impact",
abstract = "The Impact is an evolutionarily conserved gene subjected to genomic imprinting in mouse but not in human. A characteristic tandem repeat similar to those found in many other imprinted genes and an elevated expression level, both observed only for the mouse gene, are implicated in the evolution of imprinting, to which the repeat might have contributed via enhancement of the expression. To pursue the possibility further, we examined the correlation among the repeat, expression level, and imprinting of Impact in various mammals ranging from rodents, lagomorphs, carnivores, artiodactyls to primates. Intriguingly, rabbit Impact is abundantly expressed and imprinted like those of rodents, but is missing the repeat from its first intron like those of other mammals that express both alleles weakly. It thus seems that lineage-specific enhancement of gene expression rather than the tandem repeat per se played a critical role in the evolution of imprinting of Impact.",
author = "Kohji Okamura and Yoshiyuki Sakaki and Takashi Ito",
year = "2005",
month = "4",
day = "15",
doi = "10.1016/j.bbrc.2005.02.048",
language = "English",
volume = "329",
pages = "824--830",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Comparative genomics approach toward critical determinants for the imprinting of an evolutionarily conserved gene Impact

AU - Okamura, Kohji

AU - Sakaki, Yoshiyuki

AU - Ito, Takashi

PY - 2005/4/15

Y1 - 2005/4/15

N2 - The Impact is an evolutionarily conserved gene subjected to genomic imprinting in mouse but not in human. A characteristic tandem repeat similar to those found in many other imprinted genes and an elevated expression level, both observed only for the mouse gene, are implicated in the evolution of imprinting, to which the repeat might have contributed via enhancement of the expression. To pursue the possibility further, we examined the correlation among the repeat, expression level, and imprinting of Impact in various mammals ranging from rodents, lagomorphs, carnivores, artiodactyls to primates. Intriguingly, rabbit Impact is abundantly expressed and imprinted like those of rodents, but is missing the repeat from its first intron like those of other mammals that express both alleles weakly. It thus seems that lineage-specific enhancement of gene expression rather than the tandem repeat per se played a critical role in the evolution of imprinting of Impact.

AB - The Impact is an evolutionarily conserved gene subjected to genomic imprinting in mouse but not in human. A characteristic tandem repeat similar to those found in many other imprinted genes and an elevated expression level, both observed only for the mouse gene, are implicated in the evolution of imprinting, to which the repeat might have contributed via enhancement of the expression. To pursue the possibility further, we examined the correlation among the repeat, expression level, and imprinting of Impact in various mammals ranging from rodents, lagomorphs, carnivores, artiodactyls to primates. Intriguingly, rabbit Impact is abundantly expressed and imprinted like those of rodents, but is missing the repeat from its first intron like those of other mammals that express both alleles weakly. It thus seems that lineage-specific enhancement of gene expression rather than the tandem repeat per se played a critical role in the evolution of imprinting of Impact.

UR - http://www.scopus.com/inward/record.url?scp=14844304646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14844304646&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2005.02.048

DO - 10.1016/j.bbrc.2005.02.048

M3 - Article

C2 - 15752730

AN - SCOPUS:14844304646

VL - 329

SP - 824

EP - 830

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 3

ER -