Comparative genomics approach toward critical determinants for the imprinting of an evolutionarily conserved gene Impact

Kohji Okamura, Yoshiyuki Sakaki, Takashi Ito

研究成果: Contribution to journalArticle査読

16 被引用数 (Scopus)

抄録

The Impact is an evolutionarily conserved gene subjected to genomic imprinting in mouse but not in human. A characteristic tandem repeat similar to those found in many other imprinted genes and an elevated expression level, both observed only for the mouse gene, are implicated in the evolution of imprinting, to which the repeat might have contributed via enhancement of the expression. To pursue the possibility further, we examined the correlation among the repeat, expression level, and imprinting of Impact in various mammals ranging from rodents, lagomorphs, carnivores, artiodactyls to primates. Intriguingly, rabbit Impact is abundantly expressed and imprinted like those of rodents, but is missing the repeat from its first intron like those of other mammals that express both alleles weakly. It thus seems that lineage-specific enhancement of gene expression rather than the tandem repeat per se played a critical role in the evolution of imprinting of Impact.

本文言語英語
ページ(範囲)824-830
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
329
3
DOI
出版ステータス出版済み - 4 15 2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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