The class I Ag encoded the Qa/T1a regions of the murine MHC are much less polymorphic, and usually have a more restricted tissue distribution than the classical histocompatibility class I Ag, encoded by genes located in the H-2K, D, and L loci. The isolation of a quasi-ubiquitously expressed, poorly polymorphic class I gene of the T1a region of the H-2(d) mouse MHC, namely gene 37 (or T18(d)), has been recently reported. We describe the nucleotide sequence of a closely related gene, T10(c) gene, the counterpart of the gene 37 in the large duplicated parts of T1a region of the BALB/c (H-2(d)) MHC. The T10(c) gene structure and sequence are very similar to those of gene 37, but T10(c) gene is most likely a pseudogene. In A/J mouse strain, there appears to be a single gene related to 37, which is also found expressed in a variety of tissues. We show that this gene is likely to be a chimeric one derived from T10(c) for its 3' part, and from a gene closely related to gene 37 for its 5' part, which potentially encodes for an unusual class I molecule composed of the first two domains. Finally, Southern blot analysis of a number of wild mice and related animals suggests that a gene closely related to the present T10(c) gene may be the ancestor of this subfamily of class I genes characterized by the presence of an unusual second domain.
|ジャーナル||Journal of Immunology|
|出版ステータス||出版済み - 1990|
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