Comparative study on the resorbability and dissolution behavior of octacalcium phosphate, β-tricalcium phosphate, and hydroxyapatite under physiological conditions

Susumu Sakai, Takahisa Anada, Kaori Tsuchiya, Hajime Yamazaki, Henry C. Margolis, Osamu Suzuki

研究成果: Contribution to journalArticle査読

42 被引用数 (Scopus)

抄録

The dissolution behaviors of octacalcium phosphate (OCP), β-tricalcium phosphate (β-TCP), and hydroxyapatite (HA) were compared by implanting the materials in rat subcutaneous pouches for 8 weeks using a filter chamber or immersing them in simulated body fluid (SBF) or Tris-HCl buffer for 2 weeks at pH 7.4 and 37oC. X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and chemical analysis were conducted on these materials. Degree of supersaturation (DS) in the two solutions immersed with each calcium phosphate material was calculated from their chemical compositions. The results showed that OCP partially converted to apatitic crystals, while β-TCP and HA remained unchanged after the implantation. The DS of the SBF solution remained slightly supersaturated with respect to OCP and β-TCP, but slightly undersaturated in the Tris-HCl buffer. These findings suggest that previously reported OCP and β-TCP biodegradation could be induced through cell-mediated osteoclastic resorption rather than a simple dissolution process.

本文言語英語
ページ(範囲)216-224
ページ数9
ジャーナルdental materials journal
35
2
DOI
出版ステータス出版済み - 3 31 2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Dentistry(all)

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