Comparative study on the tumorigenicity in mice of gallium arsenide, gallium phosphide and gallium oxide following subcutaneous and intraperitoneal injections

Akiyo Tanaka, Akira Hisanaga, Miyuki Hirata, Noburu Ishinishi

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

Chronic toxicity, including tumorigenicity, of gallium arsenide (GaAs), gallium phosphide (GaP) and gallium oxide (Ga2O3) was studied in male ICR mice which received either a subcutaneous or an intraperitoneal injection of each material once only. The doses received either subcutaneously or intraperitoneally were 48 mg Kg−1 as Ga or 480 mg Kg−1 as Ga of each material suspended in 0.2 cm3 of olive oil. The control groups received the vehicle only, either subcutaneously or intraperitoneally. In the study using subcutaneous injections, no tumors were observed in the subcutis at the site of injection, and there was no significant difference concerning the survival periods of each group compared with the control group at the termination of the observation period. In the study using intraperitoneal injections, the total tumor incidence in all the experimental groups, except for the GaAs (480 mg Ga Kg−1) groups, was significantly different compared with the control group. However, all these tumors appeared to be spontaneous, rather than induced by the materials themselves. Moreover, in the GaAs (480 mg Ga Kg−1) and Ga2O3 (48 mg Ga Kg−1) groups, the number of survival days was significantly lower compared with the control group. From this study, it seems that neither GaAs, GaP nor Ga2O3 were tumorigenic to mice when injected subcutaneously. Although it remains unclear whether the increased production of total tumors in each group following intraperitoneal injections was directly due to the tumorigenic action of GaAs, GaP or Ga2O3 or not, it appears that these substances produce a potential systemic toxicity in mice following intraperitoneal injections.

元の言語英語
ページ(範囲)231-237
ページ数7
ジャーナルApplied Organometallic Chemistry
4
発行部数3
DOI
出版物ステータス出版済み - 1990

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Tumors
Toxicity
gallium oxide
gallium arsenide
gallium phosphide

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Inorganic Chemistry

これを引用

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abstract = "Chronic toxicity, including tumorigenicity, of gallium arsenide (GaAs), gallium phosphide (GaP) and gallium oxide (Ga2O3) was studied in male ICR mice which received either a subcutaneous or an intraperitoneal injection of each material once only. The doses received either subcutaneously or intraperitoneally were 48 mg Kg−1 as Ga or 480 mg Kg−1 as Ga of each material suspended in 0.2 cm3 of olive oil. The control groups received the vehicle only, either subcutaneously or intraperitoneally. In the study using subcutaneous injections, no tumors were observed in the subcutis at the site of injection, and there was no significant difference concerning the survival periods of each group compared with the control group at the termination of the observation period. In the study using intraperitoneal injections, the total tumor incidence in all the experimental groups, except for the GaAs (480 mg Ga Kg−1) groups, was significantly different compared with the control group. However, all these tumors appeared to be spontaneous, rather than induced by the materials themselves. Moreover, in the GaAs (480 mg Ga Kg−1) and Ga2O3 (48 mg Ga Kg−1) groups, the number of survival days was significantly lower compared with the control group. From this study, it seems that neither GaAs, GaP nor Ga2O3 were tumorigenic to mice when injected subcutaneously. Although it remains unclear whether the increased production of total tumors in each group following intraperitoneal injections was directly due to the tumorigenic action of GaAs, GaP or Ga2O3 or not, it appears that these substances produce a potential systemic toxicity in mice following intraperitoneal injections.",
author = "Akiyo Tanaka and Akira Hisanaga and Miyuki Hirata and Noburu Ishinishi",
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T1 - Comparative study on the tumorigenicity in mice of gallium arsenide, gallium phosphide and gallium oxide following subcutaneous and intraperitoneal injections

AU - Tanaka, Akiyo

AU - Hisanaga, Akira

AU - Hirata, Miyuki

AU - Ishinishi, Noburu

PY - 1990

Y1 - 1990

N2 - Chronic toxicity, including tumorigenicity, of gallium arsenide (GaAs), gallium phosphide (GaP) and gallium oxide (Ga2O3) was studied in male ICR mice which received either a subcutaneous or an intraperitoneal injection of each material once only. The doses received either subcutaneously or intraperitoneally were 48 mg Kg−1 as Ga or 480 mg Kg−1 as Ga of each material suspended in 0.2 cm3 of olive oil. The control groups received the vehicle only, either subcutaneously or intraperitoneally. In the study using subcutaneous injections, no tumors were observed in the subcutis at the site of injection, and there was no significant difference concerning the survival periods of each group compared with the control group at the termination of the observation period. In the study using intraperitoneal injections, the total tumor incidence in all the experimental groups, except for the GaAs (480 mg Ga Kg−1) groups, was significantly different compared with the control group. However, all these tumors appeared to be spontaneous, rather than induced by the materials themselves. Moreover, in the GaAs (480 mg Ga Kg−1) and Ga2O3 (48 mg Ga Kg−1) groups, the number of survival days was significantly lower compared with the control group. From this study, it seems that neither GaAs, GaP nor Ga2O3 were tumorigenic to mice when injected subcutaneously. Although it remains unclear whether the increased production of total tumors in each group following intraperitoneal injections was directly due to the tumorigenic action of GaAs, GaP or Ga2O3 or not, it appears that these substances produce a potential systemic toxicity in mice following intraperitoneal injections.

AB - Chronic toxicity, including tumorigenicity, of gallium arsenide (GaAs), gallium phosphide (GaP) and gallium oxide (Ga2O3) was studied in male ICR mice which received either a subcutaneous or an intraperitoneal injection of each material once only. The doses received either subcutaneously or intraperitoneally were 48 mg Kg−1 as Ga or 480 mg Kg−1 as Ga of each material suspended in 0.2 cm3 of olive oil. The control groups received the vehicle only, either subcutaneously or intraperitoneally. In the study using subcutaneous injections, no tumors were observed in the subcutis at the site of injection, and there was no significant difference concerning the survival periods of each group compared with the control group at the termination of the observation period. In the study using intraperitoneal injections, the total tumor incidence in all the experimental groups, except for the GaAs (480 mg Ga Kg−1) groups, was significantly different compared with the control group. However, all these tumors appeared to be spontaneous, rather than induced by the materials themselves. Moreover, in the GaAs (480 mg Ga Kg−1) and Ga2O3 (48 mg Ga Kg−1) groups, the number of survival days was significantly lower compared with the control group. From this study, it seems that neither GaAs, GaP nor Ga2O3 were tumorigenic to mice when injected subcutaneously. Although it remains unclear whether the increased production of total tumors in each group following intraperitoneal injections was directly due to the tumorigenic action of GaAs, GaP or Ga2O3 or not, it appears that these substances produce a potential systemic toxicity in mice following intraperitoneal injections.

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