Comparison between "Yusho" patients and healthy Japanese in contamination level of dioxins and related chemicals and frequency of sister chromatid exchanges

Junya Nagayama, Mayumi Nagayama, Takao Iida, Hironori Hirakawa, Takahiko Matsueda, Masafumi Ohki, Hiroshi Tsuji

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

Highly toxic organochlorine chemicals such as polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and coplanar polychlorinated biphenyls (CoPCBs) were determined in the peripheral blood and sebum from the face of 16 "Yusho" patients of about 27 yr after the outbreak of Yusho accident, and 39 healthy Japanese people. The mean total toxic equivalent (TEQ) levels of PCDDs, PCDFs and CoPCBs in the blood were still about seven times higher in Yusho patients than in healthy Japanese at the age of 45 yr and more. The sebum excretion of these chemicals seemed proportional to their blood levels in Yusho patients. These toxic chemicals, however, did not enhance frequencies of sister chromatid exchanges (SCEs) in the control and 7,8-benzoflavone (ANF) treated cultures in Yusho patients. Hence, no significant difference was observed in the mean SCE rates between the Yusho patients and general Japanese people of more than 45 yr of age. In this study, the number of Yusho patients examined is limited, so further large-scale investigations are needed to get more conclusive results concerning the genotoxic potency such as SCE induction.

元の言語英語
ページ(範囲)931-936
ページ数6
ジャーナルChemosphere
43
発行部数4-7
DOI
出版物ステータス出版済み - 5 16 2001

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Sister Chromatid Exchange
Dioxins
Poisons
dioxin
Contamination
Blood
blood
Polychlorinated Biphenyls
PCDF
Polychlorinated biphenyls
PCB
Sebum
Atrial Natriuretic Factor
exchange rate
excretion
organochlorine
accident
Accidents
Disease Outbreaks
comparison

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

これを引用

Comparison between "Yusho" patients and healthy Japanese in contamination level of dioxins and related chemicals and frequency of sister chromatid exchanges. / Nagayama, Junya; Nagayama, Mayumi; Iida, Takao; Hirakawa, Hironori; Matsueda, Takahiko; Ohki, Masafumi; Tsuji, Hiroshi.

:: Chemosphere, 巻 43, 番号 4-7, 16.05.2001, p. 931-936.

研究成果: ジャーナルへの寄稿記事

Nagayama, Junya ; Nagayama, Mayumi ; Iida, Takao ; Hirakawa, Hironori ; Matsueda, Takahiko ; Ohki, Masafumi ; Tsuji, Hiroshi. / Comparison between "Yusho" patients and healthy Japanese in contamination level of dioxins and related chemicals and frequency of sister chromatid exchanges. :: Chemosphere. 2001 ; 巻 43, 番号 4-7. pp. 931-936.
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