Comparison of injuring effects of vesicant, irritant, and nonvesicant anticancer drugs on endothelial cells

Takaaki Yamada, Nobuaki Egashira, Maiko Imuta, Ayami Bando, Takahisa Yano, Mami Saito, Ryozo Oishi

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

抄録

Anticancer drugs are classified as vesicant, irritant, and nonvesicant drugs on the basis of frequency of their vascular disorder. In this study, we compared the injuring effects of three typical anticancer drugs of each class on porcine aorta endothelial cells (PAECs). The concentration inducing 50% cell viability inhibition was lower in the order of vesicant, irritant, and nonvesicant drugs. These results suggest that injuring effects of anticancer drugs on PAECs may be relevant as an indicator of frequency of their vascular disorder, and that this experimental model may be useful for the study of vascular disorder.

元の言語英語
ページ(範囲)125-128
ページ数4
ジャーナルJournal of Pharmacological Sciences
117
発行部数2
DOI
出版物ステータス出版済み - 10 24 2011

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Irritants
Endothelial Cells
Blood Vessels
Pharmaceutical Preparations
Aorta
Swine
Cell Survival
Theoretical Models

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

これを引用

Comparison of injuring effects of vesicant, irritant, and nonvesicant anticancer drugs on endothelial cells. / Yamada, Takaaki; Egashira, Nobuaki; Imuta, Maiko; Bando, Ayami; Yano, Takahisa; Saito, Mami; Oishi, Ryozo.

:: Journal of Pharmacological Sciences, 巻 117, 番号 2, 24.10.2011, p. 125-128.

研究成果: ジャーナルへの寄稿記事

Yamada, Takaaki ; Egashira, Nobuaki ; Imuta, Maiko ; Bando, Ayami ; Yano, Takahisa ; Saito, Mami ; Oishi, Ryozo. / Comparison of injuring effects of vesicant, irritant, and nonvesicant anticancer drugs on endothelial cells. :: Journal of Pharmacological Sciences. 2011 ; 巻 117, 番号 2. pp. 125-128.
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