Comparison of MET-PET and FDG-PET for differentiation between benign lesions and malignant tumors of the lung

Masayuki Sasaki, Yasuo Kuwabara, Tsuyoshi Yoshida, Makoto Nakagawa, Hirofumi Koga, Kazutaka Hayashi, Kouichirou Kaneko, Tao Chen, Yuichi Ichiya, Kouji Masuda

研究成果: Contribution to journalArticle査読

21 被引用数 (Scopus)

抄録

Objective: We retrospectively assessed and compared the usefulness of 11C-methionine (MET)-PET with that of 18F-FDG-PET for the differentiation between benign lesions and malignant tumors of the lung. Methods: We examined 101 patients with a suspected lung tumor including 79 patients with primary lung cancer and 22 patients with benign lesions. One hundred and forty PET studies (46 studies with MET-PET and 94 studies with FDG-PET) were performed. Both MET-PET and FDG-PET were performed on 39 patients. The MET-PET was performed 15 minutes after the administration of 67-740 MBq of MET, and FDG-PET 45 minutes after the administration of 30-437 MBq of FDG. The results were then evaluated by the standardized uptake value (SUV). Results: The MET uptake in lung cancer was 3.69 ± 1.22 (n = 37) which was significantly higher than that in benign lesions 1.81 ± 1.04 (n = 9) (p < 0.001). The sensitivity, specificity and accuracy of MET-PET were 83.8%, 88.9% and 84.8%, respectively, when 2.66 of SUV was used as the cutoff value. The FDG uptake in lung cancer was 5.94 ± 2.89 (n = 75) and was also significantly larger than that in benign lesions 2.46 ± 1.01 (n = 19) (p < 0.001). The sensitivity, specificity and accuracy of FDG-PET were 81.3%, 78.9% and 80.9%, respectively (cutoff = 3.20). The MET uptake in the lesions correlated significantly with FDG uptake (r = 0.71, p < 0.001). According to an ROC analysis, the area under the curve for MET-PET (area = 0. 833) was higher than that for FDG-PET (area = 0.828), but the difference was not statistically significant. Furthermore, the combined use of MET-PET and FDG-PET did not improve the diagnostic ability. Conclusions: In conclusion, both MET-PET and FDG-PET were considered to be equally useful for the differential diagnosis of lung tumors. Furthermore, MET uptake in lung lesions was found to correlate significantly with FDG uptake.

本文言語英語
ページ(範囲)425-431
ページ数7
ジャーナルAnnals of Nuclear Medicine
15
5
DOI
出版ステータス出版済み - 2001

All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング

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