Comparison of p53 and CD44 variant 6 expression between paired primary and recurrent ovarian cancer: An immunohistochemical analysis

Toshiharu Kamura, Kunihiro Sakai, Tsunehisa Kaku, Hiroaki Kobayashi, Masamune Mitsumoto, Masazumi Tsuneyoshi, Hitoo Nakano

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

Progression of malignant potential in ovarian cancer was investigated by comparing recurrent tumor with their primary tumor counterparts in terms of p53 and CD44 variant 6 (CD44v6) expression. Forty-three paired primary and recurrent tumors were immunohistochemically evaluated for expression of p53 and CD44v6. A paired analysis revealed that p53 and CD44v6 expression were significantly greater in recurrent tumors than those in the primary counterparts with statistical significance, respectively (P=0.0055 and 0.0071; Wilcoxon signed-rank test). No relationship between these two proteins was found. These results suggested that recurrent ovarian cancer may possibly express a stronger malignant potential in comparison to the primary tumor.

本文言語英語
ページ(範囲)97-101
ページ数5
ジャーナルOncology reports
6
1
DOI
出版ステータス出版済み - 1 1 1999

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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