Comparison of PLGA reinforcement method for carbonate apatite foam

Girlie M. Munar, Melvin L. Munar, Kanji Tsuru, Kunio Ishikawa

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

1 被引用数 (Scopus)

抄録

Carbonate apatite (CO3Ap) foam with interconnecting porous structure is a potential candidate as bone substitute material owing to its similarity to the cancellous bone with respect to composition, morphology and osteoclastic degradation. However, it is brittle and difficult to handle. This is thought to be caused by no organic material in the CO3Ap foam. The aim of this study is to reinforce the CO3Ap foam with poly(DL-lactide-co-glycolide) (PLGA). Immersion and vacuum infiltration methods were compared as reinforcing methods. Compressive strength of unreinforced CO3Ap foam, (12.0 ± 4.9 kPa) increased after PLGA reinforcement by immersion (187.6 ± 57.6 kPa) or by vacuum infiltration (407 ± 111.4 kPa). Scanning electron microscopy (SEM) showed the preservation of full interconnecting porous structure of CO3Ap foam after PLGA reinforcement using immersion or vacuum infiltration. Interface between the PLGA and CO3Ap foam, however revealed that no gap was found between the PLGA and CO3Ap foam interface when vacuum was used to reinforce the PLGA whereas a gap was found when simple immersion was used. Strong interface between PLGA and CO3Ap foam is therefore thought to be the key for higher compressive strength. In conclusion, vacuum infiltration is a more efficient method to reinforce the CO3Ap foam with PLGA for improving the mechanical strength without sacrificing the cancellous bone-type morphology.

本文言語英語
ホスト出版物のタイトルBioceramics 24
ページ417-420
ページ数4
1
DOI
出版ステータス出版済み - 1 1 2013
イベント24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 - Fukuoka, 日本
継続期間: 10 21 201210 24 2012

出版物シリーズ

名前Key Engineering Materials
番号1
529-530
ISSN(印刷版)1013-9826

その他

その他24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
Country日本
CityFukuoka
Period10/21/1210/24/12

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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