抄録
Background: The most superior GFR-estimating equation from the viewpoint of cardiovascular disease (CVD) prediction remains unclear. Thus, we performed cross-sectional comparison between two GFR-estimating equations (Japanese GFR equation and coefficient-modified CKD-EPI equation) and CVD incidence using Japanese nationwide “specific health checkup” data. Methods: We recruited Japanese residents (241,159 individuals; mean 63 years; male, 38.6 %) who had not experienced CVD event (cardiac disease or stroke, or both). We calculated estimated GFR using two equations, and compared their predictive value for first symptomatic CVD event within 1 year. Results: Of all subjects, the mean GFR estimated by the Japanese GFR equation (JPN-eGFR) modified for Japanese was 75.83 ± 16.18 mL/min/1.73 m2, and that by the coefficient-modified CKD-EPI equation (mCKDEPI-eGFR) was 76.39 ± 9.61 mL/min/1.73 m2. Area under the receiver operating characteristics curves (95 % confidence intervals) for predicting CVD event by mCKDEPI-eGFR vs. JPN-eGFR were 0.596 (0.589–0.603) vs. 0.562 (0.554–0.569). Using mCKDEPI-eGFR, the crude odds ratio (OR) for CVD incident in the 4th quartile group was far more than double (OR 2.46, 95 % CI 2.29–2.66) that in the 1st quartile group. Using JPN-eGFR, the crude OR in the 4th quartile group was less than double (OR 1.61, 95 % CI 1.51–1.73) that in the 1st quartile group. However, such superior predictive value of mCKDEPI-eGFR disappeared after adjustment for confounding factors (age, gender, BMI, presence of proteinuria, hypertension, diabetes, dyslipidemia and current smoking). Conclusion: GFR estimated by the coefficient-modified CKD-EPI equation was more closely related to CVD incidence than that estimated by the Japanese GFR equation. However, it is possible that low mCKDEPI-eGFR also reflects some cardiovascular risk(s) other than kidney dysfunction.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 387-394 |
| ページ数 | 8 |
| ジャーナル | Clinical and Experimental Nephrology |
| 巻 | 19 |
| 発行部数 | 3 |
| DOI | |
| 出版物ステータス | 出版済み - 6 17 2015 |
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All Science Journal Classification (ASJC) codes
- Physiology
- Nephrology
- Physiology (medical)
これを引用
Comparison of predictive value for first cardiovascular event between Japanese GFR equation and coefficient-modified CKD-EPI equation. / Terawaki, Hiroyuki; Nakayama, Masaaki; Asahi, Koichi; Kakamu, Takeyasu; Hayakawa, Takehito; Iseki, Kunitoshi; Kimura, Kenjiro; Moriyama, Toshiki; Yamagata, Kunihiro; Narita, Ichiei; Fujimoto, Shouichi; Tsuruya, Kazuhiko; Konta, Tsuneo; Kondo, Masahide; Kurahashi, Issei; Ohashi, Yasuo; Fukushima, Tetsuhito; Watanabe, Tsuyoshi.
：: Clinical and Experimental Nephrology, 巻 19, 番号 3, 17.06.2015, p. 387-394.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Comparison of predictive value for first cardiovascular event between Japanese GFR equation and coefficient-modified CKD-EPI equation
AU - Terawaki, Hiroyuki
AU - Nakayama, Masaaki
AU - Asahi, Koichi
AU - Kakamu, Takeyasu
AU - Hayakawa, Takehito
AU - Iseki, Kunitoshi
AU - Kimura, Kenjiro
AU - Moriyama, Toshiki
AU - Yamagata, Kunihiro
AU - Narita, Ichiei
AU - Fujimoto, Shouichi
AU - Tsuruya, Kazuhiko
AU - Konta, Tsuneo
AU - Kondo, Masahide
AU - Kurahashi, Issei
AU - Ohashi, Yasuo
AU - Fukushima, Tetsuhito
AU - Watanabe, Tsuyoshi
PY - 2015/6/17
Y1 - 2015/6/17
N2 - Background: The most superior GFR-estimating equation from the viewpoint of cardiovascular disease (CVD) prediction remains unclear. Thus, we performed cross-sectional comparison between two GFR-estimating equations (Japanese GFR equation and coefficient-modified CKD-EPI equation) and CVD incidence using Japanese nationwide “specific health checkup” data. Methods: We recruited Japanese residents (241,159 individuals; mean 63 years; male, 38.6 %) who had not experienced CVD event (cardiac disease or stroke, or both). We calculated estimated GFR using two equations, and compared their predictive value for first symptomatic CVD event within 1 year. Results: Of all subjects, the mean GFR estimated by the Japanese GFR equation (JPN-eGFR) modified for Japanese was 75.83 ± 16.18 mL/min/1.73 m2, and that by the coefficient-modified CKD-EPI equation (mCKDEPI-eGFR) was 76.39 ± 9.61 mL/min/1.73 m2. Area under the receiver operating characteristics curves (95 % confidence intervals) for predicting CVD event by mCKDEPI-eGFR vs. JPN-eGFR were 0.596 (0.589–0.603) vs. 0.562 (0.554–0.569). Using mCKDEPI-eGFR, the crude odds ratio (OR) for CVD incident in the 4th quartile group was far more than double (OR 2.46, 95 % CI 2.29–2.66) that in the 1st quartile group. Using JPN-eGFR, the crude OR in the 4th quartile group was less than double (OR 1.61, 95 % CI 1.51–1.73) that in the 1st quartile group. However, such superior predictive value of mCKDEPI-eGFR disappeared after adjustment for confounding factors (age, gender, BMI, presence of proteinuria, hypertension, diabetes, dyslipidemia and current smoking). Conclusion: GFR estimated by the coefficient-modified CKD-EPI equation was more closely related to CVD incidence than that estimated by the Japanese GFR equation. However, it is possible that low mCKDEPI-eGFR also reflects some cardiovascular risk(s) other than kidney dysfunction.
AB - Background: The most superior GFR-estimating equation from the viewpoint of cardiovascular disease (CVD) prediction remains unclear. Thus, we performed cross-sectional comparison between two GFR-estimating equations (Japanese GFR equation and coefficient-modified CKD-EPI equation) and CVD incidence using Japanese nationwide “specific health checkup” data. Methods: We recruited Japanese residents (241,159 individuals; mean 63 years; male, 38.6 %) who had not experienced CVD event (cardiac disease or stroke, or both). We calculated estimated GFR using two equations, and compared their predictive value for first symptomatic CVD event within 1 year. Results: Of all subjects, the mean GFR estimated by the Japanese GFR equation (JPN-eGFR) modified for Japanese was 75.83 ± 16.18 mL/min/1.73 m2, and that by the coefficient-modified CKD-EPI equation (mCKDEPI-eGFR) was 76.39 ± 9.61 mL/min/1.73 m2. Area under the receiver operating characteristics curves (95 % confidence intervals) for predicting CVD event by mCKDEPI-eGFR vs. JPN-eGFR were 0.596 (0.589–0.603) vs. 0.562 (0.554–0.569). Using mCKDEPI-eGFR, the crude odds ratio (OR) for CVD incident in the 4th quartile group was far more than double (OR 2.46, 95 % CI 2.29–2.66) that in the 1st quartile group. Using JPN-eGFR, the crude OR in the 4th quartile group was less than double (OR 1.61, 95 % CI 1.51–1.73) that in the 1st quartile group. However, such superior predictive value of mCKDEPI-eGFR disappeared after adjustment for confounding factors (age, gender, BMI, presence of proteinuria, hypertension, diabetes, dyslipidemia and current smoking). Conclusion: GFR estimated by the coefficient-modified CKD-EPI equation was more closely related to CVD incidence than that estimated by the Japanese GFR equation. However, it is possible that low mCKDEPI-eGFR also reflects some cardiovascular risk(s) other than kidney dysfunction.
UR - http://www.scopus.com/inward/record.url?scp=84931004366&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931004366&partnerID=8YFLogxK
U2 - 10.1007/s10157-014-0997-7
DO - 10.1007/s10157-014-0997-7
M3 - Article
C2 - 25059228
AN - SCOPUS:84931004366
VL - 19
SP - 387
EP - 394
JO - Clinical and Experimental Nephrology
JF - Clinical and Experimental Nephrology
SN - 1342-1751
IS - 3
ER -