Comparison of simultaneous quantitative analysis of methylmercury and inorganic mercury in cord blood using LC-ICP-MS and LC-CVAFS: The pilot study of the Japan environment and children’s study

Miyuki Iwai-Shimada, Yayoi Kobayashi, Tomohiko Isobe, Shoji F. Nakayama, Makiko Sekiyama, Yu Taniguchi, Shin Yamazaki, Takehiro Michikawa, Masako Oda, Hiroshi Mitsubuchi, Masafumi Sanefuji, Shouichi Ohga, Nathan Mise, Akihiko Ikegami, Reiko Suga, Masayuki Shimono

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

Prenatal exposure to methylmercury (MeHg) affects child development after birth. However, many epidemiological studies have evaluated total mercury levels without analyzing speciation. Biomonitoring of MeHg and inorganic mercury (IHg) is essential to reveal each exposure level. In this study, we compared a high-throughput analysis for mercury speciation in blood using liquid chromatography-inductively coupled plasma-mass spectrometry (LC-ICP-MS) and liquid chromatography-cold vapor atomic fluorescence spectrometry (LC-CVAFS). The validated LC-ICPMS method was applied to 101 maternal blood and 366 cord blood samples in the pilot study of the Japan Environment and Children’s Study (JECS). The accuracy of the LC-CVAFS method ranged 90-115% determined by reference material analysis. To evaluate the reliability of 366 cord blood samples, fifty cord blood samples were randomly selected and analyzed using LC-CVAFS. The median (5th-95th percentile) concentrations of MeHg and IHg were 5.4 (1.9-15) and 0.33 (0.12-0.86) ng/mL, respectively, in maternal blood, and 6.3 (2.5-15) and 0.21 (0.08-0.49) ng/mL, respectively, in cord blood. Inter-laboratory comparison showed a relatively good agreement between LC-ICP-MS and LC-CVAFS. The median cord blood:maternal blood ratios of MeHg and IHg were 1.3 and 0.5, respectively. By analyzing speciation, we could focus on the health effects of each chemical form.

本文言語英語
論文番号82
ジャーナルToxics
9
4
DOI
出版ステータス出版済み - 4月 2021

!!!All Science Journal Classification (ASJC) codes

  • 毒物学
  • 化学的な安全衛生
  • 健康、毒物学および変異誘発

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