Comparison of the anti-tumor effects of selective serotonin reuptake inhibitors as well as serotonin and norepinephrine reuptake inhibitors in human hepatocellular carcinoma cells

Jun Kuwahara, Takaaki Yamada, Nobuaki Egashira, Mitsuyo Ueda, Nina Zukeyama, Soichiro Ushio, Satohiro Masuda

研究成果: Contribution to journalArticle査読

28 被引用数 (Scopus)

抄録

The anti-tumor effects of selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) on several types of cancer cells have been reported. However, comparison of the anti-tumor effects of these drugs on human hepatocellular carcinoma (HepG2) cells has not been studied. We compared the anti-tumor effects of four SSRIs and two SNRIs on HepG2 cells. SSRIs and duloxetine dose-dependently decreased cell viability. Milnacipran had no effect on cell viability. The half-maximal inhibitory concentration was lower in the order of: sertraline, paroxetine, duloxetine, fluvoxamine, escitalopram, and milnacipran. Exposure to sertraline (2 μM) significantly increased caspase-3/7 activity. These results suggest that, of the agents tested here, sertraline had the highest sensitivity to HepG2 cells, and activation of the caspase pathway is involved in the anti-tumor effects of sertraline in HepG2 cells.

本文言語英語
ページ(範囲)1410-1414
ページ数5
ジャーナルBiological and Pharmaceutical Bulletin
38
9
DOI
出版ステータス出版済み - 9 1 2015

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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