Complement activation on degraded polyethylene glycol-covered surface

Mitsuaki Toda, Yusuke Arima, Hiroo Iwata

研究成果: Contribution to journalArticle査読

14 被引用数 (Scopus)

抄録

Surface modification with polyethylene glycol (PEG) has been employed in the development of biomaterials to reduce unfavorable reactions. However, unanticipated body reactions have been reported, with activation of the complement system being suggested as having involvement in these responses. In this study, we prepared a PEG-modified surface on a gold surface using a monolayer of α-mercaptoethyl-ω-methoxy-polyoxyethylene. We observed neither protein adsorption nor activation of the complement system on the PEG-modified surface just after preparation. Storage of the PEG-modified surface in a desiccator under ambient light for several days or following ultraviolet irradiation, reflection-adsorption (FTIR-RAS) and X-ray photo spectrometry revealed deterioration of the PEG layer, which became a strong activator of the complement system through the alternative pathway.

本文言語英語
ページ(範囲)2642-2649
ページ数8
ジャーナルActa Biomaterialia
6
7
DOI
出版ステータス出版済み - 7 2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

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