Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

Takeshi Yamada, Hiroyuki Sasaki, Hirokazu Furuya, Takashi Miyata, Ikuo Goto, Yoshiyuki Sakaki

研究成果: Contribution to journalArticle査読

118 被引用数 (Scopus)


The human amyloid beta protein is a major component of brain amyloid found in patients with Alzheimer's disease. As an initial step to understand the biological function of its precursor protein, we have isolated cDNA for the mouse homolog of the human beta protein precursor. Comparison of the predicted amino acid sequence with that of human revealed a quite high degree of homology (96.8%), and the calculated evolutionary rate of the mRNA at amino acid substitution site was relatively low (0.1×10-9/site/year). The mRNA was abundant in brain and kidney, and also detected in other tissues at low level. These results indicated that this protein is highly conserved through mammalian evolution and may be involved in a basic biological process(es).

ジャーナルBiochemical and Biophysical Research Communications
出版ステータス出版済み - 12 16 1987

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学


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