Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

Takeshi Yamada, Hiroyuki Sasaki, Hirokazu Furuya, Takashi Miyata, Ikuo Goto, Yoshiyuki Sakaki

研究成果: ジャーナルへの寄稿記事

112 引用 (Scopus)

抄録

The human amyloid beta protein is a major component of brain amyloid found in patients with Alzheimer's disease. As an initial step to understand the biological function of its precursor protein, we have isolated cDNA for the mouse homolog of the human beta protein precursor. Comparison of the predicted amino acid sequence with that of human revealed a quite high degree of homology (96.8%), and the calculated evolutionary rate of the mRNA at amino acid substitution site was relatively low (0.1×10-9/site/year). The mRNA was abundant in brain and kidney, and also detected in other tissues at low level. These results indicated that this protein is highly conserved through mammalian evolution and may be involved in a basic biological process(es).

元の言語英語
ページ(範囲)665-671
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
149
発行部数2
DOI
出版物ステータス出版済み - 12 16 1987

Fingerprint

Protein Precursors
Amyloid beta-Protein Precursor
Brain
Complementary DNA
Amino Acids
Messenger RNA
Amyloid beta-Peptides
Amyloid
Biological Phenomena
Substitution reactions
Amino Acid Substitution
Tissue
Amino Acid Sequence
Alzheimer Disease
Kidney
Proteins

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

これを引用

Complementary DNA for the mouse homolog of the human amyloid beta protein precursor. / Yamada, Takeshi; Sasaki, Hiroyuki; Furuya, Hirokazu; Miyata, Takashi; Goto, Ikuo; Sakaki, Yoshiyuki.

:: Biochemical and Biophysical Research Communications, 巻 149, 番号 2, 16.12.1987, p. 665-671.

研究成果: ジャーナルへの寄稿記事

Yamada, Takeshi ; Sasaki, Hiroyuki ; Furuya, Hirokazu ; Miyata, Takashi ; Goto, Ikuo ; Sakaki, Yoshiyuki. / Complementary DNA for the mouse homolog of the human amyloid beta protein precursor. :: Biochemical and Biophysical Research Communications. 1987 ; 巻 149, 番号 2. pp. 665-671.
@article{7795da360d1645cd843dab5c56c61186,
title = "Complementary DNA for the mouse homolog of the human amyloid beta protein precursor",
abstract = "The human amyloid beta protein is a major component of brain amyloid found in patients with Alzheimer's disease. As an initial step to understand the biological function of its precursor protein, we have isolated cDNA for the mouse homolog of the human beta protein precursor. Comparison of the predicted amino acid sequence with that of human revealed a quite high degree of homology (96.8{\%}), and the calculated evolutionary rate of the mRNA at amino acid substitution site was relatively low (0.1×10-9/site/year). The mRNA was abundant in brain and kidney, and also detected in other tissues at low level. These results indicated that this protein is highly conserved through mammalian evolution and may be involved in a basic biological process(es).",
author = "Takeshi Yamada and Hiroyuki Sasaki and Hirokazu Furuya and Takashi Miyata and Ikuo Goto and Yoshiyuki Sakaki",
year = "1987",
month = "12",
day = "16",
doi = "10.1016/0006-291X(87)90419-0",
language = "English",
volume = "149",
pages = "665--671",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

AU - Yamada, Takeshi

AU - Sasaki, Hiroyuki

AU - Furuya, Hirokazu

AU - Miyata, Takashi

AU - Goto, Ikuo

AU - Sakaki, Yoshiyuki

PY - 1987/12/16

Y1 - 1987/12/16

N2 - The human amyloid beta protein is a major component of brain amyloid found in patients with Alzheimer's disease. As an initial step to understand the biological function of its precursor protein, we have isolated cDNA for the mouse homolog of the human beta protein precursor. Comparison of the predicted amino acid sequence with that of human revealed a quite high degree of homology (96.8%), and the calculated evolutionary rate of the mRNA at amino acid substitution site was relatively low (0.1×10-9/site/year). The mRNA was abundant in brain and kidney, and also detected in other tissues at low level. These results indicated that this protein is highly conserved through mammalian evolution and may be involved in a basic biological process(es).

AB - The human amyloid beta protein is a major component of brain amyloid found in patients with Alzheimer's disease. As an initial step to understand the biological function of its precursor protein, we have isolated cDNA for the mouse homolog of the human beta protein precursor. Comparison of the predicted amino acid sequence with that of human revealed a quite high degree of homology (96.8%), and the calculated evolutionary rate of the mRNA at amino acid substitution site was relatively low (0.1×10-9/site/year). The mRNA was abundant in brain and kidney, and also detected in other tissues at low level. These results indicated that this protein is highly conserved through mammalian evolution and may be involved in a basic biological process(es).

UR - http://www.scopus.com/inward/record.url?scp=0023598244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023598244&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(87)90419-0

DO - 10.1016/0006-291X(87)90419-0

M3 - Article

C2 - 3322280

AN - SCOPUS:0023598244

VL - 149

SP - 665

EP - 671

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -