Comprehensive Analysis of Analogues of Amine-Related Psychoactive Substances Using Femtosecond Laser Ionization Mass Spectrometry

Siddihalu Lakshitha Madunil, Totaro Imasaka, Tomoko Imasaka

研究成果: ジャーナルへの寄稿学術誌査読

抄録

Amine-related psychoactive molecules contain N–Cα and Cα–Cβ bonds, which easily dissociate to form various fragment ions in electron ionization mass spectrometry (EIMS). Therefore, observing a molecular ion and then determining the molecular weight of the analyte is difficult. In this study, we examined phenethylamine, 3,4-methylenedioxyphenethylamine, tryptamine, N-methylephedrine, and nicotine as well as analogues of amine-related psychoactive substances using EIMS and femtosecond laser ionization mass spectrometry (fs-LIMS) combined with gas chromatography for comprehensive analysis. A molecular ion was clearly observed in fs-LIMS for all of these compounds, which was in contrast to EIMS providing fragment ions dominantly (no molecular ion was observed for N-methylephedrine). This favorable result was obtained by adjusting the laser wavelength to the optimal value for two-photon ionization to minimize the excess energy remaining in the molecular ion. It therefore appears that fs-LIMS is superior to EIMS in terms of observing a molecular ion and would be potentially useful for identifying a variety of amine-related psychoactive substances, some of which are illegal and are of interest in the field of forensic science.

本文言語英語
ページ(範囲)90-99
ページ数10
ジャーナルJournal of the American Society for Mass Spectrometry
33
1
DOI
出版ステータス出版済み - 1月 5 2022

!!!All Science Journal Classification (ASJC) codes

  • 構造生物学
  • 分光学

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